ReviewChemical science2018
Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
Review in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
176 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shaking Things from the Ground-Up: A Systematic Overview of the Mechanochemistry of Hard and High-Melting Inorganic Materials.Molecules (Basel, Switzerland) · 2023Pooled it
- Force-driven single-molecule transformations through tip-mediated stabilization of transition states.Nature communications · 2026Article
- Mechanochemical generation of chlorine dioxide radical for solvent-free oxygenation of dibenzothiophenes.RSC advances · 2026Article
- Advances in Perimidine Derivative Synthesis: From Classical Condensation to Dehydrogenative Coupling and Borrowing Hydrogen Strategies.Topics in current chemistry (Cham) · 2026Review
- From ball-milling to bead-milling technology: rapid optimization and scale-up of a one-pot Wittig olefination-Diels-Alder reaction sequence using an agitator bead mill.RSC mechanochemistry · 2026Article
- Mechanochemical Integration of Incompatible Reaction Environments for the One-Pot Synthesis of Structurally Diverse N-Heterocycles.ChemSusChem · 2026Article
- Mechanochemical Diastereoselective Substrate-Directed Synthesis of Pyrrole-Isoxazolidines via 1,3-Dipolar Cycloaddition of Maleimides with Nitrones.The Journal of organic chemistry · 2026Article
- Mechanochemically assembled organometallic complexes: a mechanistic study.Chemical science · 2026Article
- Mechanochemical Dehydrogenative Phenochalcogenazination: A Pronounced Water Effect.ChemSusChem · 2026Article
- Systematic Scale-Up of Mechanochemical Paracetamol-Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies.Organic process research & development · 2026Article
- Mechanochemical SChemSusChem · 2026Article
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- A reflection on synthesis by extrusion ten years on: achievements, challenges and opportunities for solvent-free, sustainable, continuous chemical manufacturing.Chemical science · 2026Article
- The role of ball mass, surface, and contact dynamics in mechanochemical reactions.RSC mechanochemistry · 2026Article
- Green Condensation of Aromatic Aldehydes and Barbituric Acid Enabled by Spiral Gas-Solid Flow.ACS omega · 2026Article
- Mechanochemical modification ofRSC advances · 2026Article
- A Mechanochemical Kolbe-Schmitt Reaction: Catechol Carboxylation Provides Building Blocks for Renewable Plasticizers.Angewandte Chemie (International ed. in English) · 2026Article
- Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Mechanochemical Deep Impact: Delivering Sustainable Synthesis and Hydrogen Innovation.ChemSusChem · 2026Article
- From waste rubber to value polybutadiene modification for circular materials.Nature communications · 2026Review
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with 'direct' comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.