Evidence map›Paper›PMID 29780387›Full record

ArticleFrontiers in immunology2018

CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.

Genevieve E Martin, Matthew Pace, John P Thornhill, Chansavath Phetsouphanh, Jodi Meyerowitz, Morgane Gossez, Helen Brown, Natalia Olejniczak, Julianne Lwanga, Gita Ramjee and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lymph-Node-Based CD3Journal of virology · 2023
    Article
  7. CD20Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  8. Article
  9. Article
  10. CD32iScience · 2021
    Article
  11. CD32Frontiers in immunology · 2021
    Article
  12. Review
  13. Review
  14. Different human resting memory CD4Science translational medicine · 2020
    Observational
  15. Observational
  16. Measuring the Success of HIV-1 Cure Strategies.Frontiers in cellular and infection microbiology · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Genevieve E MartinPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Matthew PacePeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
John P ThornhillPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Chansavath PhetsouphanhPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jodi MeyerowitzPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Morgane GossezPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Helen BrownPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Natalia OlejniczakPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Julianne LwangaDepartment of Genitourinary Medicine and Infectious Disease, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Gita RamjeeHIV Prevention Research Unit, South African Medical Research Council, Durban, South Africa.
Pontiano KaleebuUganda Virus Research Institute (MRC), Entebbe, Uganda.
Kholoud PorterResearch Department of Infection and Population Health, University College London, London, United Kingdom.
Christian B WillbergPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Paul KlenermanPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nneka NwokoloChelsea and Westminster Hospital, London, United Kingdom.
Julie FoxDepartment of Genitourinary Medicine and Infectious Disease, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Sarah FidlerDivision of Medicine, Wright Fleming Institute, Imperial College, London, United Kingdom.
John FraterPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Medawar Building for Pathogen Research · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College London · GBChelsea and Westminster Hospital · GBSouth African Medical Research Council · ZAUganda Virus Research Institute · UGUniversity College London · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_U122886351Medical Research Council MC_UU_00027/1Medical Research Council MC_UU_12023/15Medical Research Council MR/L00528X/1Medical Research Council MR/L006588/1Medical Research Council MR/N001265/1Medical Research Council MR/P011233/1Wellcome Trust 109965/Z/15/Z
6 · The paper itself

Abstract

Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting biomarker. CD32a (FcγRIIa) has been proposed to be a marker for an enriched CD4 T cell HIV reservoir, but this finding remains controversial. Here, we explore the expression of CD32 on CD3

Indexed as

PhenotypeProvirusesAdultBiomarkersCD4 Lymphocyte CountCD4-Positive T-LymphocytesDNA, ViralFemaleGene ExpressionHIV-1HIV InfectionsHumansImmunologic MemoryImmunophenotypingMaleReceptors, HIVBiomarkersDNA, ViralReceptors, HIVReceptors, IgGRNA, ViralCD32HIVHIV DNAprimary HIV infectionreservoir

Identifiers

PMID29780387
PMCPMC5946760
OpenAlexW2802581766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.