Evidence map›Paper›PMID 29780318›Full record

ArticleFrontiers in aging neuroscience2018

The Aerobic and Cognitive Exercise Study (ACES) for Community-Dwelling Older Adults With or At-Risk for Mild Cognitive Impairment (MCI): Neuropsychological, Neurobiological and Neuroimaging Outcomes of a Randomized Clinical Trial.

Cay Anderson-Hanley, Nicole M Barcelos, Earl A Zimmerman, Robert W Gillen, Mina Dunnam, Brian D Cohen, Vadim Yerokhin, Kenneth E Miller, David J Hayes, Paul J Arciero and 2 more

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 87 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 13 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05009524 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Interactive Physical and Cognitive Exercise System (iPACES v3) to Benefit Brain Health in Mild Cognitive Impairment (MCI): A Randomized Clinical Trial of Neuro-exergaming Pedal-to-play (iPACES) vs Pedal-while-play (PACE)

TypeinterventionalSponsoriPACES LLCRan2021 to 2022Enrolled120ConditionsMCI, Mild Cognitive Impairment, Alzheimer Disease, DementiaArmsiPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
NCT05810454 nanot yet recruitingnot on this mapstarted 2023, after this paper: background citation

Neuro-exergaming for the Prevention and Remediation of Decline Due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES-PD)

TypeinterventionalSponsoriPACES LLCRan2023 to 2026Enrolled120ConditionsParkinson's Disease, PD, Mild Cognitive Impairment, MCIArmsiPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
NCT06755164 naactive not recruitingnot on this mapstarted 2019, after this paper: background citation

Effects of Combined Aerobic and Cognitive Training in a Simultaneous or Sequential Paradigm on Cognition and Brain Functional Activity in Patients with Amnesic Mild Cognitive Impairment

TypeinterventionalSponsorIRCCS San RaffaeleRan2019 to 2025Enrolled55ConditionsMild Cognitive Impairment (MCI), AMCI - Amnestic Mild Cognitive Impairment, Neurodegenerative Dementia, Neurodegenerative DiseaseArmsSimultaneous aerobic and cognitive training (SIM), Sequential aerobic and cognitive training (SEQ)
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 13 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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  5. Exergaming for dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2024
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Cay Anderson-HanleyThe Healthy Aging and Neuropsychology Lab, Union College, Schenectady, NY, United States.
Nicole M BarcelosThe Healthy Aging and Neuropsychology Lab, Union College, Schenectady, NY, United States.
Earl A ZimmermanAlzheimer's Disease Center, Albany Medical Center, Albany, NY, United States.
Robert W GillenSunnyview Rehabilitation Hospital, Schenectady, NY, United States.
Mina DunnamStratton VA Medical Center, Albany, NY, United States.
Brian D CohenDepartment of Biology, Union College, Schenectady, NY, United States.
Vadim YerokhinBiomedical Sciences Department, Oklahoma State University, Tulsa, OK, United States.
Kenneth E MillerDepartment of Anatomy and Cell Biology, Oklahoma State University, Tulsa, OK, United States.
David J HayesThe Healthy Aging and Neuropsychology Lab, Union College, Schenectady, NY, United States.
Paul J ArcieroDepartment of Health & Human Physiological Sciences, Skidmore College, Saratoga Springs, NY, United States.
Molly MaloneyThe Healthy Aging and Neuropsychology Lab, Union College, Schenectady, NY, United States.
Arthur F KramerBeckman Institute, University of Illinois, Urbana-Champaign, Champaign, IL, United States.
Union College · USOklahoma State University · USAlbany Medical Center Hospital · USAlbany Stratton VA Medical Center Albany · USSkidmore College · USUniversity of Illinois Urbana-Champaign · US

Funding

Cognitive Benefits of Interactive Mental and Physical Exercise for MCIR15AG042109 · NIA · UNION COLLEGE · PI ANDERSON-HANLEY, CAY · 2013 to 2013
$330k
NIA NIH HHS R15 AG042109
6 · The paper itself

Abstract

Prior research has found that cognitive benefits of physical exercise and brain health in older adults may be enhanced when mental exercise is interactive simultaneously, as in exergaming. It is unclear whether the cognitive benefit can be maximized by increasing the degree of mental challenge during exercise. This randomized clinical trial (RCT), the Aerobic and Cognitive Exercise Study (ACES) sought to replicate and extend prior findings of added cognitive benefit from exergaming to those with or at risk for mild cognitive impairment (MCI). ACES compares the effects of 6 months of an

Indexed as

agingAlzheimer's diseasecognitivedementiaexerciseexergameMCIneuropsychological

Identifiers

PMID29780318
PMCPMC5945889
OpenAlexW2802979508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.