ArticleFrontiers in cellular neuroscience2018
Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Maternal high-fat diet exposure is associated with altered hypothalamic microglial development and reduced early postnatal TGFβ1 signaling in male offspring.Frontiers in endocrinology · 2026Article
- Microglia/macrophage polarization regulates spontaneous remyelination in intermittent cuprizone model of demyelination.Biochemistry and biophysics reports · 2024Article
- Microglia in Glioma.Advances in neurobiology · 2024Review
- Receptors on Microglia.Advances in neurobiology · 2024Review
- Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus.Journal of integrative neuroscience · 2021Article
- Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury.Journal of neuroinflammation · 2021Article
- TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?Aging and disease · 2020Review
- Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis.Journal of neuroinflammation · 2020Article
- Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.Journal of neuroinflammation · 2019Article
- Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype.Frontiers in cellular neuroscience · 2019Article
- Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10).Frontiers in cellular neuroscience · 2018Article
- Sex- and Development-Dependent Responses of Rat Microglia to Pro- and Anti-inflammatory Stimulation.Frontiers in cellular neuroscience · 2018Article
- Maternal obesity and developmental programming of neuropsychiatric disorders: An inflammatory hypothesis.Brain and neuroscience advancesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytokine, transforming growth factor β1 (TGFβ1), is up-regulated after central nervous system (CNS) injuries or diseases involving microglial activation, and it has been proposed as a therapeutic agent for treating neuroinflammation. Microglia can produce and respond to TGFβ1. While rats and mice are commonly used for studying neuroinflammation, very few reports directly compare them. Such studies are important for improving pre-clinical studies and furthering translational progress in developing therapeutic interventions. After intracerebral hemorrhage (ICH) in the rat striatum, the TGFβ1 receptor was highly expressed on microglia/macrophages within the hematoma. We recently found species similarities and differences in response to either a pro-inflammatory (interferon-γ, IFN-γ, +tumor necrosis factor, TNF-α) or anti-inflammatory interleukin-4 (IL-4) stimulus. Here, we assessed whether rat and mouse microglia differ in their responses to TGFβ1. Microglia were isolated from Sprague-Dawley rats and C57BL/6 mice and treated with TGFβ1. We quantified changes in expression of >50 genes, in their morphology, proliferation, apoptosis and in three potassium channels that are considered therapeutic targets. Many inflammatory mediators, immune receptors and modulators showed species similarities, but notable differences included that, for some genes, only one species responded (e.g.,
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