ArticleClinical epidemiology2018
High mortality due to cutaneous melanoma in Norway: a study of prognostic factors in a nationwide cancer registry.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Assessing the clinical, humanistic, and economic impact of early cancer diagnosis: a systematic literature review.Frontiers in oncology · 2025Pooled it
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- Stimulation of Skin Pigmentation with UVR Is a Risk Factor for Cholelithiasis.JID innovations : skin science from molecules to population health · 2025Review
- Overview of skin cancer types and prevalence rates across continents.Cancer pathogenesis and therapy · 2025Review
- From trials to practice: Immune checkpoint inhibitor therapy for melanoma patients in Norway.Acta oncologica (Stockholm, Sweden) · 2024Article
- Article
- Melanoma Mortality Trends in 28 European Countries: A Retrospective Analysis for the Years 1960-2020.Cancers · 2023Article
- High regional mortality due to malignant melanoma in Eastern Finland may be explained by the increase in aggressive melanoma types.BMC cancer · 2021Article
- Article
- Multivariate analysis of prognostic factors in patients with nodular melanoma.Journal of cancer research and clinical oncology · 2021Article
- Phenotypic Characteristics and Melanoma Thickness in Women.Acta dermato-venereologica · 2021Article
- Clinical Suspicion Sensitivity of Nodular and Superficial Spreading Melanoma.Acta dermato-venereologica · 2021Article
- Subtyping Cutaneous Melanoma Matters.JNCI cancer spectrum · 2020Article
- RNAi-mediated IARS2 knockdown inhibits proliferation and promotes apoptosis in human melanoma A375 cells.Oncology letters · 2020Article
- Informing patients about their mutation tests: CDKN2A c.256G>A in melanoma as an example.Hereditary cancer in clinical practice · 2020Article
- Second Primary Cancers in Melanoma Patients Critically Shorten Survival.Clinical epidemiology · 2020Article
- Histopathological pattern of skin cancer in Western region of Saudi Arabia. An 11 years experience.Saudi medical journal · 2018Article
- Proposal for the applicability of modified Breslow (measured from the basal membrane) as a predictor of survival and sentinel lymph node outcome in patients with cutaneous melanoma.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to examine why Norway has the highest rate of mortality due to cutaneous melanoma (CM) in Europe. The Norwegian Malignant Melanoma Registry (NMMR) enables the study of clinical and histopathological characteristics of patients who die due to CM.
resultsThe NMMR and the Norwegian Cause of Death Registry provided data on the clinical and histopathological factors as well as the date and cause of death, through June 2015 for all first invasive CMs diagnosed in 2008-2012 (n=8087). Cox regression was used to estimate associations between clinical and pathological factors and CM-specific death. Multiple imputation was used to handle missing data.
resultsThe CMs were equally distributed between men (49.9%) and women (50.1%), and the median follow-up was 4.0 years (range: 0.08-7.5 years). Trunk was the most common anatomic site (48%), superficial spreading melanoma was the dominant melanoma subtype (68.2%), median Breslow thickness was 1.0 mm, ulceration was present in 23% of CMs, and 91.8% of cases were in a local clinical stage at diagnosis. Compared to women, men were diagnosed at a higher age, with thicker and more-often-ulcerated tumor, and more often were in advanced clinical stages. During follow-up, 1015 patients died due to CM, representing 52.8% of all deaths. The nodular subtype made up the dominant proportion of fatal CM cases (55.3% in women, 64.6% in men). Sex, age, anatomic site (trunk), T-stage, ulceration, clinical stage, and having a second primary CM were associated with increased risk of CM-specific death.
conclusionOur data suggest that the high rate of mortality due to CM observed in Norway is attributable to the more advanced stage of the disease at diagnosis. Most high-risk cases occurred in male patients ≥70 years of age. Efforts to improve awareness and secondary prevention of CM, including warning signs of all melanoma subtypes, are required urgently and should be targeted toward men in particular.
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