Evidence map›Paper›PMID 29780196›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering

Light Fluence Dosimetry in Lung-simulating Cavities.

Timothy C Zhu, Michele M Kim, Jonah Padawer, Andreea Dimofte, Mary Potasek, Karl Beeson, Evgueni Parilov

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A Monte Carlo simulation for Moving Light Source in Intracavity PDT.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timothy C ZhuDepartment of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
Michele M KimDepartment of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
Jonah PadawerDepartment of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
Andreea DimofteDepartment of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
Mary PotasekSimphotek Inc, 211 Warren St, NJ.
Karl BeesonSimphotek Inc, 211 Warren St, NJ.
Evgueni ParilovSimphotek Inc, 211 Warren St, NJ.

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Image-guided treatment planning for pleural Photodynamic TherapyR01CA154562 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2012 to 2016
$1.6M
Development of Novel Fast GPU Monte Carlo and Active Photonics Simulation Software for Predicting PDT EfficacyR44CA183236 · NCI · SIMPHOTEK, INC. · PI CARY, JOHN R, POTASEK, MARY · 2016 to 2017
$1.5M
Development of Novel Fast GPU Monte Carlo and Active Photonics Simulation SoftwarR43CA183236 · NCI · SIMPHOTEK, INC. · PI PARILOV, EVGUENI, POTASEK, MARY · 2014 to 2014
$225k
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA154562NCI NIH HHS R43 CA183236NCI NIH HHS R44 CA183236
6 · The paper itself

Abstract

Accurate light dosimery is critical to ensure consistent outcome for pleural photodynamic therapy (pPDT). Ellipsoid shaped cavities with different sizes surrounded by turbid medium are used to simulate the intracavity lung geometry. An isotropic light source is introduced and surrounded by turbid media. Direct measurements of light fluence rate were compared to Monte Carlo simulated values on the surface of the cavities for various optical properties. The primary component of the light was determined by measurements performed in air in the same geometry. The scattered component was found by submerging the air-filled cavity in scattering media (Intralipid) and absorbent media (ink). The light source was located centrally with the azimuthal angle, but placed in two locations (vertically centered and 2 cm below the center) for measurements. Light fluence rate was measured using isotropic detectors placed at various angles on the ellipsoid surface. The measurements and simulations show that the scattered dose is uniform along the surface of the intracavity ellipsoid geometries in turbid media. One can express the light fluence rate empirically as

Indexed as

intra-cavitary treatment planninglight dosimetrylight fluenceMC simulationPhotodynamic therapy

Identifiers

PMID29780196
PMCPMC5959279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.