ArticleClinical science (London, England : 1979)2018
The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers.
Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02627872 (Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Thoracic muscle loss increases the use of mechanical ventilation in elderly patients with pulmonary embolism: constructing and validating a machine learning model on a two-center cohort.BMC geriatrics · 2026Article
- Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025Review
- Article
- Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.Respiratory research · 2024Article
- Systemic increase in IL-26 is associated with severe COVID-19 and comorbid obstructive lung disease.Frontiers in immunology · 2024Article
- Increased interleukin-26 in the peripheral joints of patients with axial spondyloarthritis and psoriatic arthritis, co-localizing with CD68-positive synoviocytes.Frontiers in immunology · 2024Article
- TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26.Frontiers in immunology · 2023Article
- IL-26 in the Lung and Its Role in COPD Inflammation.Journal of personalized medicine · 2022Review
- Involvement of IL-26 in bronchiolitis obliterans syndrome but not in acute rejection after lung transplantation.Respiratory research · 2022Article
- Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19.Frontiers in immunology · 2022Article
- Complex Involvement of Interleukin-26 in Bacterial Lung Infection.Frontiers in immunology · 2021Article
- Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats.Inhalation toxicology · 2020Article
- Granulocyte-targeted therapies for airway diseases.Pharmacological research · 2020Review
- Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women.Journal of asthma and allergy · 2020Article
- Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts.Frontiers in pharmacology · 2019Article
- IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense.Frontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26 (IL-26) is involved in airway inflammation amongst long-term tobacco smokers with or without COPD, chronic bronchitis or colonization by pathogenic bacteria. By analyzing bronchoalveolar lavage (BAL), bronchail wash (BW) and induced sputum (IS) samples, we found increased extracellular IL-26 protein in the airways of long-term smokers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.