ArticleSchizophrenia research2019
Childhood trauma and clinical high risk for psychosis.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Sedative Effects of Inhaled Nebulized Dexmedetomidine on Children: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Psychosis-like experiences and resilience: A systematic and critical review of the literature.Psychological services · 2022Pooled it
- A randomized trial of telehealth mindfulness-based cognitive therapy and cognitive behavioral therapy groups for adolescents with mood or attenuated psychosis symptoms.Journal of consulting and clinical psychology · 2023Trial
- Dissociation, Childhood Trauma, and Emotion Processing in Individuals with Elevated Psychosis-like Experiences: A Theoretical Framework of Cognitive Integration.Brain sciences · 2026Article
- Childhood trauma, specifically emotional abuse, is associated with psychiatric symptom severity in drug‑naïve first‑episode patients with schizophrenia.Scientific reports · 2026Article
- Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE.Lupus science & medicine · 2026Article
- Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- CaMKII Neurons in the Dentate Gyrus Are Involved in Regulating Cognitive Impairment in Mice Induced by Stress Caused by Violence.International journal of molecular sciences · 2025Article
- Childhood trauma and parenting in at-risk mental state: Clarifying pathways and expanding perspectives.World journal of psychiatry · 2025Article
- Psychiatric Antecedents in Adolescents at Clinical High Risk for Psychosis: Insights from the "Parma At-Risk Mental States" Follow-up Program.Research on child and adolescent psychopathology · 2025Article
- Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control.European archives of psychiatry and clinical neuroscience · 2025Article
- Machine learning in psychiatric health records: A gold standard approach to trauma annotation.Translational psychiatry · 2025Article
- Mediational effect analysis of childhood emotional abuse on prodromal psychotic symptoms in self-taught examination students.Scientific reports · 2025Article
- Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders.Schizophrenia bulletin · 2025Article
- Observational
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Article
- The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders.Schizophrenia research · 2024Article
- Working memory performance is related to childhood trauma but not psychotic-like experiences in a nonpsychiatric sample.Psychological trauma : theory, research, practice and policy · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61%) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of suspiciousness. Trauma was unrelated to specific measures of social and role functioning. A small proportion of CHR participants were diagnosed with formal PTSD (14%), which was unrelated to symptom severity or functioning. Thus, we demonstrate that trauma exposure is often early in life (before age 12), occurs prior to the onset of the CHR syndrome, and is related to both positive and affective symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.