Evidence map›Paper›PMID 29779950›Full record

ArticleCell2018

The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

Jeffrey E Markowitz, Winthrop F Gillis, Celia C Beron, Shay Q Neufeld, Keiramarie Robertson, Neha D Bhagat, Ralph E Peterson, Emalee Peterson, Minsuk Hyun, Scott W Linderman and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed
24.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 465 citations in OpenAlex.

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  18. Dopamine modulation of aggression.Psychopharmacology · 2026
    Review
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  20. Article

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jeffrey E MarkowitzDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Winthrop F GillisDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Celia C BeronDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Shay Q NeufeldDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Keiramarie RobertsonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Neha D BhagatDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Ralph E PetersonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Emalee PetersonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Minsuk HyunDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Scott W LindermanGrossman Center for the Statistics of Mind, Columbia University, New York, NY, USA; Departments of Statistics and Computer Science, Columbia University, New York, NY, USA.
Bernardo L SabatiniDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Sandeep Robert DattaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: srdatta@hms.harvard.edu.
Howard Hughes Medical Institute · USHarvard University · USColumbia University · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Gabriel Kreiman · 1998 to 2026
$21.3M
Characterizing the Functional Architecture of the Necklace Olfactory SystemR01DC016222 · NIDCD · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2017 to 2021
$2.8M
Lagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor SequencesU01NS094191 · NINDS · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R, SABATINI, BERNARDO L · 2015 to 2018
$1.9M
Characterizing Odor Maps in the Olfactory Bulb and CortexR01DC011558 · NIDCD · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2011 to 2015
$1.8M
Novel optrodes for large-scale electrophysiology and site-specific stimulationU01NS094190 · NINDS · HARVARD MEDICAL SCHOOL · PI ASSAD, JOHN, BERDONDINI, LUCA · 2015 to 2017
$1.6M
NEI NIH HHS P30 EY012196NICHD NIH HHS P30 HD018655NIDCD NIH HHS R01 DC011558NIDCD NIH HHS R01 DC016222NINDS NIH HHS U01 NS094190NINDS NIH HHS U01 NS094191
6 · The paper itself

Abstract

Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural activity in the direct and indirect pathways of dorsolateral striatum (DLS) as mice spontaneously express action sequences. These experiments reveal that DLS neurons systematically encode information about the identity and ordering of sub-second 3D behavioral motifs; this encoding is facilitated by fast-timescale decorrelations between the direct and indirect pathways. Furthermore, lesioning the DLS prevents appropriate sequence assembly during exploratory or odor-evoked behaviors. By characterizing naturalistic behavior at neural timescales, these experiments identify a code for elemental 3D pose dynamics built from complementary pathway dynamics, support a role for DLS in constructing meaningful behavioral sequences, and suggest models for how actions are sculpted over time.

Indexed as

Behavior, AnimalAnimalsCalciumCorpus StriatumElectrodes, ImplantedFemaleMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsN-MethylaspartatePhotometryReceptors, Dopamine D1CalciumDrd1 protein, mouseN-MethylaspartateReceptors, Dopamine D1basal gangliabehaviorcodingdirect pathwayethologyindirect pathwaymachine learningmousephotometrystriatum

Identifiers

PMID29779950
PMCPMC6026065
OpenAlexW2804636914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.