ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2018
White matter disruptions in patients with bipolar disorder.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- White Matter Abnormalities in Bipolar II and Unipolar Depression - Evidence from Fixel-Based Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Investigating structural-functional brain covariation in bipolar disorder using a multimodal fusion approach.Brain imaging and behavior · 2025Article
- A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits.Acta neuropsychiatrica · 2023Article
- Widespread intra-axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment.Human brain mapping · 2023Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- White matter integrity in young medication-naïve bipolar II depressed adults.Scientific reports · 2021Article
- Comparison of White Matter Structure of Drug-Naïve Patients With Bipolar Disorder and Major Depressive Disorder Using Diffusion Tensor Tractography.Frontiers in psychiatry · 2021Article
- Neuroanatomic and Functional Neuroimaging Findings.Current topics in behavioral neurosciences · 2021Article
- White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents.Psychiatry research. Neuroimaging · 2020Article
- Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis.NPJ schizophrenia · 2020Article
- Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Age-Related Alterations of White Matter Integrity in Adolescents and Young Adults With Bipolar Disorder.Frontiers in psychiatry · 2019Article
- State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study.Journal of psychiatry & neuroscience : JPNArticle
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Funding
Abstract
Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics. Fractional anisotropy (FA) and Mean Diffusivity (MD) were determined. Patients had significantly lower FA and higher MD values throughout the white matter skeleton compared to controls. Within the BD patients, lithium use was associated with higher FA and lower MD. Antipsychotic medication use in the BD patients was not associated with FA but, in contrast to lithium, was associated with higher MD. IQ was significantly positively correlated with FA and negatively with MD in patients as well as in controls. In this large DTI study we found evidence for marked differences in FA and MD particularly in (but not restricted to) corpus callosum, between BD patients and controls. This effect was most pronounced in lithium-free patients, implicating that lithium affects white matter microstructure and attenuates differences associated with bipolar disorder. Effects of antipsychotic medication intake were absent in FA and only subtle in MD relative to those of lithium. The abnormal white matter microstructure was associated with IQ but not specifically for either group.
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