ArticleOphthalmology2018
The Relationship of Retinal Vessel Geometric Characteristics to the Incidence and Progression of Diabetic Retinopathy.
Article in Ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Trends and hotspots in the field of diabetic retinopathy imaging research from 2000-2023.Frontiers in medicine · 2024Pooled it
- High-salt intake affects retinal vascular tortuosity in healthy males: an exploratory randomized cross-over trial.Scientific reports · 2021Trial
- Application of nanozyme-based drug delivery systems in the treatment of ROS-related ophthalmic diseases.International journal of pharmaceutics: X · 2026Review
- Retinal Vascular Features and Risk of Colorectal Cancer Incidence and Mortality: A Population-Based Cohort Study.Ophthalmology and therapy · 2026Article
- Reproducibility in the identification of retinal positions on serial fundus photographs: Theory and limitations.Acta ophthalmologica · 2026Article
- Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways.International journal of oral science · 2026Article
- Deep learning retinal imaging model identifies poor brain health among older adults without dementia.Cerebral circulation - cognition and behavior · 2026Article
- Potential of Pterostilbene as an Antioxidant Therapy for Delaying Retinal Damage in Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2025Article
- Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study.Investigative ophthalmology & visual science · 2025Article
- Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation.Investigative ophthalmology & visual science · 2024Article
- AI-based fully automatic analysis of retinal vascular morphology in pediatric high myopia.BMC ophthalmology · 2024Article
- Combining functional and morphological retinal vascular characteristics achieves high-precision diagnosis of mild non-proliferative diabetic retinopathy.Journal of translational medicine · 2024Article
- Computational Retinal Microvascular Biomarkers from an OCTA Image in Clinical Investigation.Biomedicines · 2024Article
- Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study.Acta diabetologica · 2024Article
- Distinctive Imaging Characteristics of Retinal and Cerebral Vessels between Central and Branch Retinal Vein Occlusion by MRI and AI-Based Image Analyzer.Diagnostics (Basel, Switzerland) · 2024Article
- Automated evaluation of retinal hyperreflective foci changes in diabetic macular edema patients before and after intravitreal injection.Frontiers in medicine · 2023Article
- The impact of the image conversion factor and image centration on retinal vessel geometric characteristics.Frontiers in medicine · 2023Article
- Quantitative assessment of retinal microvascular remodeling in eyes that underwent idiopathic epiretinal membrane surgery.Frontiers in cell and developmental biology · 2023Article
- Alterations in Coronary Resistance Artery Network Geometry in Diabetes and the Role of Tenascin C.Reviews in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeTo examine the relationships of retinal vessel geometric characteristics (RVGCs) to the incidence and progression of diabetic retinopathy (DR).
designObservational, prospective cohort study.
participantsNine hundred ninety-six persons with type 1 diabetes mellitus (T1DM) and 1370 persons with type 2 diabetes mellitus (T2DM) seen at a baseline examination who were eligible for follow-up examinations at subsequent 5-year intervals. A total of 3846 person-interval data from these follow-up examinations are the basis for the analyses.
methodsDiabetic retinopathy and macular edema were assessed by grading of 30° stereoscopic color fundus photographs. Retinal vessel geometric characteristics were assessed using the Singapore I Vessel Assessment program from a digitized copy of 1 of the field 1 fundus photographs obtained at baseline and follow-up.
main outcome measuresThe 5-year incidence of any DR, progression of DR, and incidence of proliferative diabetic retinopathy (PDR) and clinically significant macular edema (CSME) in right eyes.
resultsIncident DR occurred in 45%, progression in 32%, PDR in 10%, and CSME in 5%. While adjusting for glycated hemoglobin, duration of diabetes, and other factors, retinal arteriolar simple tortuosity was associated significantly with the incidence of any DR (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.01-1.35). Retinal venular branching angle was associated significantly with progression of DR (OR, 1.18; 95% CI, 1.03-1.36), retinal venular curvature tortuosity was associated significantly with the incidence of PDR (OR, 1.15; 95% CI, 1.01-1.30), and retinal venular branching angle (OR, 1.41; 95% CI, 1.10-1.82) was associated significantly with the incidence of CSME. There were no significant associations of other RVGCs with any of the DR outcomes in the full multivariate model. Inclusion of all possible RVGCs did not improve the predictive value of the models that already included retinal vessel diameter and baseline DR severity level.
conclusionsRetinal vessel geometric characteristics of the retinal venules were associated with progression of DR; however, most of the RVGCs measured from digitized fundus photographs added little to the assessment of risk of incidence and progression of DR when other risk factors were considered in T1DM and T2DM.
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