ArticleBiological psychiatry2018
Resting-State Connectivity Biomarkers of Cognitive Performance and Social Function in Individuals With Schizophrenia Spectrum Disorder and Healthy Control Subjects.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Implementing Precision Psychiatry: A Systematic Review of Individualized Prediction Models for Clinical Practice.Schizophrenia bulletin · 2021Pooled it
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Autism and Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Multivariate relationships between social cognitive performance and functional connectivity during task and rest across schizophrenia spectrum disorders and healthy controls.Molecular psychiatry · 2026Article
- Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations With Cognition and Functioning.Human brain mapping · 2026Article
- Prognostic Biomarkers and Precision Psychiatry: A Review of the Available Evidence.Biomedicines · 2026Review
- Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia.Schizophrenia research. Cognition · 2025Article
- Early-stage diagnosis of HIV-associated neurocognitive disorders via multiple learning models based on resting-state functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Association Between Optical Coherence Tomography Angiography (OCTA)-Based Retinal Vascular Densities and Empathy in Young Adults.Bioengineering (Basel, Switzerland) · 2025Article
- Multivariate Association Between Functional Connectivity Gradients and Cognition in Schizophrenia Spectrum Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Alterations in local activity and whole-brain functional connectivity in human immunodeficiency virus-associated neurocognitive disorders: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders.Molecular autism · 2024Article
- Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- SAN: Mitigating spatial covariance heterogeneity in cortical thickness data collected from multiple scanners or sites.Human brain mapping · 2024Article
- SAN: mitigating spatial covariance heterogeneity in cortical thickness data collected from multiple scanners or sites.bioRxiv : the preprint server for biology · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDeficits in neurocognition and social cognition are drivers of reduced functioning in schizophrenia spectrum disorders, with potentially shared neurobiological underpinnings. Many studies have sought to identify brain-based biomarkers of these clinical variables using a priori dichotomies (e.g., good vs. poor cognition, deficit vs. nondeficit syndrome).
methodsWe evaluated a fully data-driven approach to do the same by building and validating a brain connectivity-based biomarker of social cognitive and neurocognitive performance in a sample using resting-state and task-based functional magnetic resonance imaging (n = 74 healthy control participants, n = 114 persons with schizophrenia spectrum disorder, 188 total). We used canonical correlation analysis followed by clustering to identify a functional connectivity signature of normal and poor social cognitive and neurocognitive performance.
resultsPersons with poor social cognitive and neurocognitive performance were differentiated from those with normal performance by greater resting-state connectivity in the mirror neuron and mentalizing systems. We validated our findings by showing that poor performers also scored lower on functional outcome measures not included in the original analysis and by demonstrating neuroanatomical differences between the normal and poorly performing groups. We used a support vector machine classifier to demonstrate that functional connectivity alone is enough to distinguish normal and poorly performing participants, and we replicated our findings in an independent sample (n = 75).
conclusionsA brief functional magnetic resonance imaging scan may ultimately be useful in future studies aimed at characterizing long-term illness trajectories and treatments that target specific brain circuitry in those with impaired cognition and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.