Evidence map›Paper›PMID 29779262›Full record

ArticleJournal of clinical periodontology2018

Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.

Karolina E Kaczor-Urbanowicz, Harsh M Trivedi, Patricia O Lima, Paulo M Camargo, William V Giannobile, Tristan R Grogan, Frederico O Gleber-Netto, Yair Whiteman, Feng Li, Hyo Jung Lee and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  11. Microbial extracellular RNAs and their roles in human diseases.Experimental biology and medicine (Maywood, N.J.) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 4 countries.

Karolina E Kaczor-UrbanowiczUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.ORCID 0000-0001-9243-3652
Harsh M TrivediEarly Research Oral Care, Colgate Palmolive Co., Piscataway, New Jersey.
Patricia O LimaUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.
Paulo M CamargoSection of Periodontics, UCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
William V GiannobileDepartment of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-7102-9746
Tristan R GroganDepartment of Biostatistics, University of California at Los Angeles, Los Angeles, California.
Frederico O Gleber-NettoMedical Genomics Laboratory, Centro Internacional de Pesquisa e Ensino (CIPE), AC Camargo Cancer Center, São Paulo, Brazil.
Yair WhitemanUCLA School of Dentistry, Center for Esthetic Dentistry, University of California at Los Angeles, Los Angeles, California.
Feng LiUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.
Hyo Jung LeeSection of Dentistry, Department of Periodontology, Seoul National University Bundang Hospital, Seoul, Korea.
Karan DhariaUCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
Katri AroUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.
Carmen Martin Carreras-PresasFaculty of Biomedical Sciences, Adult's Dentistry Department, Universidad Europea de Madrid, Madrid, Spain.ORCID 0000-0002-0937-0994
Saarah AmuthanUCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
Manjiri VartakUCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
David AkinUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.
Hiba Al-AdbullahUCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
Kanika BembeyUCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
Perry R KlokkevoldSection of Periodontics, UCLA School of Dentistry, University of California at Los Angeles, Los Angeles, California.
David ElashoffDepartment of Biostatistics, University of California at Los Angeles, Los Angeles, California.
Virginia M BarnesClinical Research Oral Care, Colgate Palmolive Co., Piscataway, New Jersey.
Rose RichterClinical Research Oral Care, Colgate Palmolive Co., Piscataway, New Jersey.
William DeVizioClinical Research Oral Care, Colgate Palmolive Co., Piscataway, New Jersey.
James G MastersEarly Research Oral Care, Colgate Palmolive Co., Piscataway, New Jersey.
David T W WongUCLA School of Dentistry, Center for Oral/Head & Neck Oncology Research, University of California at Los Angeles, Los Angeles, California.
University of California, Los Angeles · USColgate-Palmolive (United States) · USAC Camargo Hospital · BRSeoul National University Bundang Hospital · KRUniversidad Europea de Madrid · ESUniversity of Michigan · US

Funding

Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH3TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2015 to 2017
$2.7M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramR90DE023057 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2016
$416k
NCATS NIH HHS UH3 TR000923NIDCR NIH HHS R90 DE023057NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

aimThis study tests the hypothesis that salivary extracellular RNA (exRNA) biomarkers can be developed for gingivitis detection and monitoring disease regression. MATERIALS AND

methodsSalivary exRNA biomarker candidates were developed from a total of 100 gingivitis and non-gingivitis individuals using Affymetrix's expression microarrays. The top 10 differentially expressed exRNAs were tested in a clinical cohort to determine whether the discovered salivary exRNA markers for gingivitis were associated with clinical gingivitis and disease regression. For this purpose, unstimulated saliva was collected from 30 randomly selected gingivitis subjects, the gingival and plaque indexes scores were taken at baseline, 3 and 6 weeks and salivary exRNAs were assayed by means of reverse transcription quantitative polymerase chain reaction.

resultsEight salivary exRNA biomarkers developed for gingivitis were statistically significantly changed over time, consistent with disease regression. A panel of four salivary exRNAs [SPRR1A, lnc-TET3-2:1, FAM25A, CRCT1] can detect gingivitis with a clinical performance of 0.91 area under the curve, with 71% sensitivity and 100% specificity.

conclusionsThe clinical values of the developed salivary exRNA biomarkers are associated with gingivitis regression. They offer strong potential to be advanced for definitive validation and clinical laboratory development test.

Indexed as

GingivitisBiomarkersDental Plaque IndexGingivaHumansSalivaBiomarkersbiomarkersexRNAgingivitismonitoringsaliva

Identifiers

PMID29779262
PMCPMC6023773
OpenAlexW2803690975

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.