Evidence map›Paper›PMID 29779179›Full record

SynthesisThe international journal of cardiovascular imaging2018

Clinical outcomes of complete revascularization using either angiography-guided or fractional flow reserve-guided drug-eluting stent implantation in non-culprit vessels in ST elevation myocardial infarction patients: insights from a study based on a systematic review and meta-analysis.

Alexandre Hideo-Kajita, Hector M Garcia-Garcia, Kayode O Kuku, Solomon S Beyene, Viana Azizi, Yael F Meirovich, Gebremedhin D Melaku, Aaphtaab Dheendsa, Echo J Brathwaite, Sameer Desale and 5 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Alexandre Hideo-KajitaDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Hector M Garcia-GarciaDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA. hector.m.garciagarcia@medstar.net.
Kayode O KukuDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Solomon S BeyeneDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Viana AziziDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Yael F MeirovichDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Gebremedhin D MelakuDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Aaphtaab DheendsaDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Echo J BrathwaiteDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Sameer DesaleDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Mohammad SoudDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Kazuhiro DanDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Yuichi OzakiDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Ron WaksmanDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
Michael LipinskiDivision of Interventional Cardiology, MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, 110 Irving Street, East Building, Suite 4B-1, Washington, DC, 20010, USA.
MedStar Washington Hospital Center · USResearch Network (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current guidelines recommend that percutaneous coronary intervention (PCI) should be restricted to the culprit vessel in ST elevation myocardial infarction (STEMI) patients with multi-vessel disease (MVD) and without cardiogenic shock. However, newer data suggests that performing complete revascularization (CR) in MVD patients may lead to better outcomes compared to intervention in the culprit vessel only. The aim of this meta-analysis is to examine the available data to determine if CR (using either angio- or fractional flow reserve guidance-FFR) following primary PCI in STEMI patients without cardiogenic shock impacts clinical outcomes. Meta-analysis was performed by conducting a literature search of PubMed from January 2004 to July 2017. Pooled estimates of outcomes, presented as odds ratios (OR) [95% confidence intervals], were generated using random-effect models. A total of 9 studies (3317 patients) were included. CR showed a significant MACE reduction (OR 0.49, 95% CI 0.36-0.66, p < 0.001); All-cause mortality (OR 0.69, 95% CI 0.48-0.98, p = 0.04) and repeat revascularization (OR 0.38, 95% CI 0.28-0.51, p < 0.001) at ≥ 12 months follow-up. The FFR-guiding CR group presented a MACE reduction (odds ratio 0.52, 95% CI 0.30-0.90, p = 0.02) due to a decrease of repeat revascularization (OR 0.41, 95% CI 0.21-0.80, p = 0.009). Overall, performing complete revascularization in STEMI patients showed a MACE reduction, all-cause death and repeat revascularization. Compared to culprit-only revascularization, treating multi-vessel disease in STEMI patients using FFR guidance is associated with decreased incidence of MACE, due to a decreased rate of revascularization.

Indexed as

Drug-Eluting StentsPercutaneous Coronary InterventionCoronary AngiographyCoronary Artery DiseaseFractional Flow Reserve, MyocardialHumansMyocardial RevascularizationST Elevation Myocardial InfarctionTreatment OutcomeDrug-eluting stentFractional flow reserveMeta-analysisSTEMI complete revascularizationSystematic review

Identifiers

PMID29779179
OpenAlexW2803943125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.