ArticleSleep & breathing = Schlaf & Atmung2019
Arousal index as a marker of carotid artery atherosclerosis in patients with obstructive sleep apnea syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04399200 (Sleep Apnea Syndrome and Incidence of Major Adverse Cardiac and Cerebrovascular Events), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Apnea Syndrome and Incidence of Major Adverse Cardiac and Cerebrovascular Events (MACCEs) After a First Stroke
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Redefining Obstructive Sleep Apnea: Multidimensional Phenotyping Beyond the Apnea-Hypopnea Index.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy.Nature and science of sleep · 2025Article
- Article
- Sleep disturbance exacerbates atherosclerosis in type 2 diabetes mellitus.Frontiers in cardiovascular medicine · 2023Article
- Association between Arousals during Sleep and Subclinical Coronary Atherosclerosis in Patients with Obstructive Sleep Apnea.Brain sciences · 2022Article
- Long-term outcomes regarding arterial stiffness and carotid artery atherosclerosis in female patients with rapid eye movement obstructive sleep apnea.The Journal of international medical research · 2022Article
- Association Between Sleep Duration and Sleep Disorder Data from the National Health and Nutrition Examination Survey and Stroke Among Adults in the United States.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Respiratory Arousals in Patients with Very Severe Obstructive Sleep Apnea and How They Change after a Non-Framework Surgery.Healthcare (Basel, Switzerland) · 2022Article
- [Arousal characteristics in different OSAHS populations].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Effect of Nighttime Earplugs and Eye Masks on Sleep Quality in Intensive Care Unit Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Relationship Between Sleep Apnea and Coronary Artery Calcium in Patients With Ischemic Stroke.Frontiers in neurology · 2019Article
- Sleep Fragmentation and Atherosclerosis: is There a Relationship?Missouri medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt was shown in a previous cohort study that men with internal carotid artery (ICA) plaque, defined as focal wall thickness of ≥ 1.5 mm, had a threefold higher risk of stroke than those without plaque. We examined the relationship between arousal indices and sleep stages in patients with obstructive sleep apnea syndrome (OSAS) and carotid atherosclerosis.
methodsCarotid atherosclerosis severity was evaluated using the maximal carotid wall intima-media thickness of the ICA (ICA-maxIMT) and plaque in 83 patients with OSAS.
resultsThe ICA-maxIMT values were positively correlated with the apnea hypopnea index (AHI) (ρ = 0.294, P = 0.007), arousal index (ρ = 0.289, P = 0.008), oxygen desaturation index (ρ = 0.298, P = 0.006), percentage of visually scored total sleep time spent in nocturnal oxygen saturation < 90% (SpO
conclusionsSeveral PSG variables that are indicative of sleep fragmentation, sleep disordered breathing, and poor sleep quality correlated with the occurrence of atherosclerosis, but total arousal index was the only independent predictive factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.