ArticleInternational journal of clinical oncology2018
Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing.
Article in International journal of clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Tumors of the Nose and Paranasal Sinuses: Promoting Factors and Molecular Mechanisms-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Pooled it
- Occupational exposure and risk clusters in malignant transformation of inverted sinonasal papilloma.Scientific reports · 2025Article
- EGFR mutations in sinonasal squamous neoplasms: Novel hotspot for exon 20 insertions.Virchows Archiv : an international journal of pathology · 2025Article
- Assessment of TP53 and CDKN2A status as predictive markers of malignant transformation of sinonasal inverted papilloma.Scientific reports · 2024Article
- Pathogenesis of chemically induced nasal cavity tumors in rodents: contribution to adverse outcome pathway.Journal of toxicologic pathology · 2024Review
- An in vitro model and the underlying pathways of sinonasal inverted papilloma development.Scientific reports · 2023Article
- Human Papillomavirus Infection andJournal of personalized medicine · 2023Article
- Molecular Basis and Rationale for the Use of Targeted Agents and Immunotherapy in Sinonasal Cancers.Journal of clinical medicine · 2022Review
- Sinonasal Inverted Papilloma and Squamous Cell Carcinoma: Contemporary Management and Patient Outcomes.Cancers · 2022Review
- Establishment and genetic characterization of cell lines derived from proliferating nasal polyps and sinonasal inverted papillomas.Scientific reports · 2021Article
- EGFR and BRAF mutations in inverted sinonasal papilloma - a more complex landscape?Virchows Archiv : an international journal of pathology · 2021Article
- Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer.Scientific reports · 2021Article
- Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.Current oncology reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated.
methodsTo clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing.
resultsThe number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene.
conclusionIdentification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.