Evidence map›Paper›PMID 29779108›Full record

ArticleDoklady. Biochemistry and biophysics2018

MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells.

V A Tarasov, M G Tyutyakina, M A Makhotkin, E F Shin, A V Naboka, A N Mashkarina, D A Chebotarev, E N Cherkasova, M I Kogan, M B Chibichyan and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

V A TarasovSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
M G TyutyakinaSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia. tyutyakina@mail.ru.
M A MakhotkinSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
E F ShinSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
A V NabokaSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
A N MashkarinaSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
D A ChebotarevSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
E N CherkasovaSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
M I KoganSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
M B ChibichyanSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
D G MatishovSouthern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, 3444006, Russia.
Southern Scientific Center · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.

Indexed as

Cell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHormonesHumansMaleMicroRNAsProstatic NeoplasmsReceptor, IGF Type 1Receptors, SomatomedinHormonesIGF1R protein, humanMicroRNAsReceptor, IGF Type 1Receptors, Somatomedin

Identifiers

PMID29779108
OpenAlexW2804974278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.