Evidence map›Paper›PMID 29779099›Full record

ArticleDoklady. Biochemistry and biophysics2018

The Differential Expression of Adhesion Molecule and Extracellular Matrix Genes in Mesenchymal Stromal Cells after Interaction with Cord Blood Hematopoietic Progenitors.

L B Buravkova, E R Andreeva, M V Lobanova, E V Cotnezova, A I Grigoriev

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Autologous cord blood in children with cerebral palsy: a review.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

L B BuravkovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia. buravkova@imbp.ru.
E R AndreevaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia.
M V LobanovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia.
E V CotnezovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia.
A I GrigorievInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia.
Institute of Biomedical Problems · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dynamics of the expression of genes encoding adhesion molecules, molecules of the connective tissue matrix, and its remodeling enzymes was studied in multipotent mesenchymal stromal cells (MSCs) from human adipose tissue after interaction with cord blood hematopoietic progenitors (HSPCs). An upregulation of ICAM1 and VCAM1, directly proportional to the coculture time (24-72 h), was found. After 72 h of culturing, a downregulation of the genes encoding the majority of matrix molecules (SPP1; COL6A2,7A1; MMP1,3; TIMP1,3; and HAS1) and cell-matrix adhesion molecules (ITGs) was revealed. The detected changes may ensure the realization of the stromal MSC function due to improvement of adhesion and transmigration of HSPCs into the subcellular space.

Indexed as

Cell CommunicationGene Expression RegulationHematopoiesisCell Adhesion MoleculesExtracellular MatrixFetal BloodHumansMesenchymal Stem CellsCell Adhesion Molecules

Identifiers

PMID29779099
OpenAlexW2803731634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.