Evidence map›Paper›PMID 29779097›Full record

ArticleDoklady. Biochemistry and biophysics2018

MNT Optimization for Intracellular Delivery of Antibody Fragments.

A V Ulasov, Y V Khramtsov, T N Lupanova, A D Tsvetkova, A A Rosenkranz, T A Slastnikova, G P Georgiev, A S Sobolev

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A V UlasovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Y V KhramtsovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
T N LupanovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
A D TsvetkovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
A A RosenkranzInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
T A SlastnikovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
G P GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
A S SobolevInstitute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. sobolev@igb.ac.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the possibility of optimizing modular nanotransporters (MNTs) for the intracellular delivery of antibody fragments into the nuclei of cells of a specified type. Basic MNT with a reduced size retaining the desired functions was obtained, and the principal possibility of obtaining an MNT carrying an antibody fragment by microbiological synthesis was shown.

Indexed as

Cell Line, TumorDrug CarriersHumansIntracellular SpaceNanostructuresSingle-Chain AntibodiesDrug CarriersSingle-Chain Antibodies

Identifiers

PMID29779097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.