Evidence map›Paper›PMID 29779071›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2018

Steady-state PERG adaptation: a conspicuous component of response variability with clinical significance.

P Monsalve, S Ren, G Triolo, L Vazquez, A D Henderson, M Kostic, P Gordon, W J Feuer, V Porciatti

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06388096 (CLAD Deconvolved PERG Responses in Glaucoma Patients), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06388096 naunknown statusnot on this mapstarted 2023, after this paper: background citation

CLAD Deconvolved PERG Responses in Glaucoma Patients

TypeinterventionalSponsorJorvec Corp.Ran2023 to 2025Enrolled120ConditionsGlaucoma, SuspectArmsPattern Electroretinogram
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Compartmental Differences in Macular Retinal Ganglion Cell Function.Translational vision science & technology · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

P MonsalveBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
S RenBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
G TrioloHead and Neck Department, IRCCS St. Raffaele Hospital, Milan, Italy.
L VazquezBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
A D HendersonJohns Hopkins Wilmer Eye Institute, Columbia, MD, USA.
M KosticBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
P GordonBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
W J FeuerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
V PorciattiBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. vporciatti@med.miami.edu.ORCID http://orcid.org/0000-0002-1592-3532

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
RETINAL GANGLION CELL PLASTICITY IN GLAUCOMAR01EY019077 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PORCIATTI, VITTORIO · 2009 to 2015
$2.1M
NEI NIH HHS P30-EY014801NEI NIH HHS RO1 EY019077Research to Prevent Blindness Unrestricted to Bascom Palmer Eye Institute
6 · The paper itself

Abstract

purposeTo investigate within-test variability of the steady-state PERG (SS-PERG).

methodsSS-PERGs were recorded in response to black-white horizontal gratings (1.6 cycles/deg, 98% contrast, 15.63 reversals/s, LED display, 25 deg square field, 800 cd/sqm mean luminance) using skin electrodes. PERG and noise (± reference) signals were averaged over 1024 epochs (~ 2.2 min) and Fourier analyzed to retrieve SS-PERG amplitude and phase. SS-PERGs were split into 16 partial averages (samples) of 64 epochs each, and corresponding amplitudes and phases combined in polar coordinates to assess their dispersion (within-test variability). To assess time-dependent variability, samples were clustered in four successive time segments of ~ 33 s each. Amplitude adaptation was defined as amplitude difference between initial and final clusters, and PERG phase adaptation as the corresponding phase difference. To determine the dynamic range of SS-PERG adaptation, recording was performed in normal controls of different age (n = 32) and patients with different severity of optic nerve dysfunction (early manifest glaucoma, EMG, n = 7; non-arteritic ischemic optic neuropathy, NAION, n = 5).

resultsAmplitude adaptation was largest in younger controls (amplitude adaptation ÷ noise, SNR = 9.5, 95% CI 13.1, 5.9) and progressively decreased with increasing age (older subjects, SNR = 5.5, 95% CI 9.2, 1.8) and presence of disease (EMG: SNR = 2.4, 95% CI 3.5, 1.4; NAION: SNR = 1.9, 95% CI 6.5,-2.2). In 11 young subjects, amplitude adaptation was repeatable (test-retest in two sessions a week apart; intraclass correlation coefficient = 0.59). Phase adaptation was not significantly different from zero in all groups.

conclusionsSS-PERG adaptation accounts for a sizeable portion of the within-test variability. As it has robust SNR, sufficient test-retest variability, and is altered in disease, it may have physiological and clinical significance. This study suggests that SS-PERG protocols should include adaptation in addition to SS-PERG amplitude and phase/latency.

Indexed as

AdultAgedElectrodesElectroretinographyFemaleGlaucomaHumansMaleMiddle AgedOptic Neuropathy, IschemicPattern Recognition, VisualRetinal Ganglion CellsYoung AdultGlaucomaNeural adaptationNon-arteritic ischemic optic neuropathyPattern electroretinogramVariability

Identifiers

PMID29779071

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.