Evidence map›Paper›PMID 29779037›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer.

Marcos Custódio, Cibele Pelissari, Thalita Santana, Marília Trierveiler

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. The role of OCT4 and CD44 in lower lip carcinogenesis.Oral and maxillofacial surgery · 2025
    Article
  2. Possible role of ALDH1 and CD44 in lip carcinogenesis.Journal of applied oral science : revista FOB · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marcos CustódioDepartment of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Cibele PelissariDepartment of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Thalita SantanaDepartment of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
Marília TrierveilerDepartment of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil. trierveiler@usp.br.ORCID http://orcid.org/0000-0002-8517-2105
Universidade de São Paulo · BR

Funding

Fapesp 08/54606-9
6 · The paper itself

Abstract

purposeThe aim of this work was to evaluate the expression of the cancer stem cell (CSC) markers CD44, ALDH1 and p75NTR in the ultraviolet-induced lesions actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC), and to correlate it with p53 expression.

methodsImmunohistochemistry was performed in 4 cases of normal lip (NL), 43 of AC and 20 of LSCC.

resultsAll cases were positive for CD44, showing a membranous staining without differences between the groups. ALDH1 showed cytoplasmic staining and it was invariable amongst the grades of epithelial dysplasia and between AC and LSCC. p75NTR presented membranous/cytoplasmic staining in the basal and parabasal layer of NL and AC, while LSCC presented cytoplasmic staining in the peripheral layers of the tumor islands. p75NTR showed different expression amongst the dysplasia grades (p < 0.001) but no differences between AC and LSCC. p53 expression was similar amongst the dysplasia grades and between AC and LSCC. CD44, ALDH1 and p75NTR were unrelated amongst themselves and to p53 expression.

conclusionsCSC markers are expressed in potentially malignant and malignant lesions of the lip. Their expressions were invariable between AC and LSCC and unrelated to p53. p75NTR expression increased with the worsening of epithelial dysplasia grade.

Indexed as

AdultAgedAged, 80 and overAldehyde Dehydrogenase 1 FamilyBiomarkersCarcinoma, Squamous CellCheilitisFemaleHumansHyaluronan ReceptorsImmunohistochemistryIsoenzymesLip NeoplasmsMaleMiddle AgedNeoplastic Stem CellsAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanBiomarkersCD44 protein, humanHyaluronan ReceptorsIsoenzymesNerve Tissue ProteinsNGFR protein, humanReceptors, Nerve Growth FactorRetinal DehydrogenaseActinic cheilitisCancer stem cellsHead and neck neoplasmsLip neoplasmsUltraviolet radiation

Identifiers

PMID29779037
OpenAlexW2803562732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.