ArticleJACC. Cardiovascular imaging2019
Multicenter Randomized Controlled Crossover Trial Comparing Hemodynamic Optimization Against Echocardiographic Optimization of AV and VV Delay of Cardiac Resynchronization Therapy: The BRAVO Trial.
Article in JACC. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01258829 (British Randomised Controlled Trial of AV and VV Optimisation), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
British Randomised Controlled Trial of AV and VV Optimisation (BRAVO): Randomised Clinical Trial of the Effects of Non-invasive Haemodynamic Optimisation of Cardiac Resynchronisation Devices on Exercise Capacity
Who cites it
19 citing papers in PubMed.
- Atrioventricular Delay Optimization in His-Optimized Cardiac Resynchronization Therapy: A Case Report.Clinical case reports · 2026Article
- High-Precision Hemodynamic and Echocardiographic Assessment of Pacing in Obstructive Hypertrophic Cardiomyopathy.Pacing and clinical electrophysiology : PACE · 2025Article
- Article
- An implantable system to restore hemodynamic stability after spinal cord injury.Nature medicine · 2025Article
- Usefulness of Cardiac Resynchronization Therapy Optimization Using Combined Electrocardiography and Echocardiography.Cureus · 2025Article
- Optimizing outcomes from cardiac resynchronization therapy: what do recent data and insights say?Expert review of cardiovascular therapy · 2024Review
- Maximizing QRS duration reduction in contemporary cardiac resynchronization therapy is feasible and shorter QRS duration is associated with better clinical outcome.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Frontiers in conduction system pacing: treatment of long PR in patients with heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Clinical outcomes of automatic algorithms in cardiac resynchronization therapy: Systematic review and meta-analysis.Heart rhythm O2 · 2023Article
- Cardiac Resynchronization Therapy beyond Nominal Settings: An IEGM-Based Approach for Paced and Sensed Atrioventricular Delay Offset Optimization in Daily Clinical Practice.Journal of clinical medicine · 2023Article
- Inefficient diastolic filling in dual-chamber pacemaker recipients: impact of atrio-ventricular interval shortening (AVI-SHORT study).Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Managing arrhythmia in cardiac resynchronisation therapy.Frontiers in cardiovascular medicine · 2023Review
- Optimizing atrio-ventricular delay in pacemakers using potentially implantable physiological biomarkers.Pacing and clinical electrophysiology : PACE · 2022Article
- Non-invasive hemodynamic determination of patient-specific optimal pacing mode in cardiac resynchronization therapy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy: Role of Multimodality Imaging.Diagnostics (Basel, Switzerland) · 2021Review
- A multicenter prospective randomized controlled trial of cardiac resynchronization therapy guided by invasive dP/dt.Heart rhythm O2 · 2021Article
- Article
- Multipoint Pacing with Fusion-optimized Cardiac Resynchronization Therapy: Using It All to Narrow QRS Duration.The Journal of innovations in cardiac rhythm management · 2021Article
- His Resynchronization Versus Biventricular Pacing in Patients With Heart Failure and Left Bundle Branch Block.Journal of the American College of Cardiology · 2018Article
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Authors and funding
28 authors.
Funding
Abstract
objectivesBRAVO (British Randomized Controlled Trial of AV and VV Optimization) is a multicenter, randomized, crossover, noninferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular delay with a noninvasive blood pressure method.
backgroundCardiac resynchronization therapy including AV delay optimization confers clinical benefit, but the optimization requires time and expertise to perform.
methodsThis study randomized patients to echocardiographic optimization or hemodynamic optimization using multiple-replicate beat-by-beat noninvasive blood pressure at baseline; after 6 months, participants were crossed over to the other optimization arm of the trial. The primary outcome was exercise capacity, quantified as peak exercise oxygen uptake. Secondary outcome measures were echocardiographic left ventricular (LV) remodeling, quality-of-life scores, and N-terminal pro-B-type natriuretic peptide.
resultsA total of 401 patients were enrolled, the median age was 69 years, 78% of patients were men, and the New York Heart Association functional class was II in 84% and III in 16%. The primary endpoint, peak oxygen uptake, met the criterion for noninferiority (p
conclusionsOptimization of cardiac resynchronization therapy devices by using noninvasive blood pressure is noninferior to echocardiographic optimization. Therefore, noninvasive hemodynamic optimization is an acceptable alternative that has the potential to be automated and thus more easily implemented. (British Randomized Controlled Trial of AV and VV Optimization [BRAVO]; NCT01258829).
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