Evidence map›Paper›PMID 29778775›Full record

ArticleDrug and alcohol dependence2018

Prenatal exposures to tobacco and cannabis: Associations with adult electronic cigarette use.

Natacha M De Genna, Gale A Richardson, Lidush Goldschmidt, Nancy L Day, Marie D Cornelius

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Natacha M De GennaUniversity of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: degennan@pitt.edu.
Gale A RichardsonUniversity of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: gar@pitt.edu.
Lidush GoldschmidtWestern Psychiatric Institute and Clinic (WPIC) at University of Pittsburgh Medical Center (UPMC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: lidush@pitt.edu.
Nancy L DayUniversity of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: nday@pitt.edu.
Marie D CorneliusUniversity of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: mdc1@pitt.edu.
University of Pittsburgh · USUPMC Health System · US

Funding

Maternal Age, Trajectories of Substance Use, and Health DisparitiesR01DA037209 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DE GENNA, NATACHA · 2014 to 2016
$864k
NIDA NIH HHS R01 DA037209
6 · The paper itself

Abstract

introductionPrenatal exposures to tobacco and cannabis are associated with combustible cigarette use. This study evaluated pathways from these prenatal exposures to adult electronic cigarette use. We tested whether there were indirect effects of these prenatal exposures via childhood behavior dysregulation, early tobacco use, and adolescent tobacco dependence.

methodsTelephone interviews were conducted with 427 adult offspring (22-33 years old) from 3 prenatal cohorts with trimester-specific data on exposures to tobacco, alcohol, and cannabis. The offspring were 59% Black and 41% White (61% female). Prenatal exposures included quantity/frequency of tobacco, alcohol, and cannabis use by mothers during the first trimester. Using logistic regression and structural equation modeling, we examined the effects of gestational exposures on adult electronic cigarette use via early cigarette use (prior to age 14), controlling for covariates of combustible and electronic cigarette use.

resultsThere were no effects of childhood behavioral dysregulation on electronic cigarette use. However, there was a significant indirect effect of prenatal exposures to tobacco and cannabis on electronic cigarette use via early adolescent combustible cigarette use and adolescent risk for tobacco dependence.

conclusionsOne implication of these findings is that the inter-generational risk for tobacco use conferred via gestational exposures to tobacco and cannabis generalizes to novel products such as electronic cigarettes. These results have implications for public health, as more women use cannabis and co-use cigarettes and cannabis during pregnancy.

Indexed as

AdultAge of OnsetCannabisElectronic Nicotine Delivery SystemsEthanolFemaleHumansMaleMothersPregnancyPrenatal Exposure Delayed EffectsTobacco ProductsTobacco UseUnited StatesYoung AdultEthanolCannabisElectronic cigarettesPrenatal cannabisPrenatal exposuresPrenatal tobaccoTobacco dependence

Identifiers

PMID29778775
PMCPMC6038701
OpenAlexW2800560903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.