Evidence map›Paper›PMID 29778523›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2018

Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury.

Jonghyuck Park, Joseph T Decker, Daniel J Margul, Dominique R Smith, Brian J Cummings, Aileen J Anderson, Lonnie D Shea

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025
    Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jonghyuck ParkDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Joseph T DeckerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Daniel J MargulDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Dominique R SmithDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Brian J CummingsDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Aileen J AndersonDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: ldshea@umich.edu.
University of Michigan–Ann Arbor · USUniversity of California, Irvine · USNorthwestern University · US

Funding

Controlled Release Scaffolds for Nerve RegenerationR01EB005678 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2007 to 2018
$6.0M
NIBIB NIH HHS R01 EB005678
6 · The paper itself

Abstract

Trauma to the spinal cord and associated secondary inflammation can lead to permanent loss of sensory and motor function below the injury level, with the resulting environment serving as a barrier that limits regeneration. In this study, we investigate the localized expression of anti-inflammatory cytokines IL-10 and IL-4 via lentiviral transduction in multichannel bridges. Porous multichannel bridges provide physical guidance for axonal outgrowth with the cytokines hypothesized to modulate the neuroinflammatory microenvironment and enhance axonal regeneration. Gene expression analyses indicated that induced IL-10 and IL-4 expression decreased expression of pro-inflammatory genes and increased pro-regenerative genes relative to control. Moreover, these factors led to increased numbers of axons and myelination, with approximately 45% of axons myelinated and the number of oligodendrocyte myelinated axons significantly increased by 3- to 4-fold. Furthermore, the combination of a bridge with IL-10 and IL-4 expression improved locomotor function after injury to an average score of 6 relative to an average score of 3 for injury alone. Collectively, these studies highlight the potential for localized immunomodulation to decrease secondary inflammation and enhance regeneration that may have numerous applications.

Indexed as

AnimalsAnti-Inflammatory AgentsAxonsCell LineCytokinesFemaleHEK293 CellsHumansImmunomodulationInterleukin-10LentivirusMiceMice, Inbred C57BLMyelin SheathNerve RegenerationOligodendrogliaAnti-Inflammatory AgentsCytokinesInterleukin-10anti-inflammatory cytokinesimmunoengineeringlentiviral gene deliverymultichannel bridgespinal cord injury

Identifiers

PMID29778523
PMCPMC6037204
OpenAlexW2801458258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.