ArticleReproductive biology and endocrinology : RB&E2018
Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome.
Article in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Moderate-intensity physical activity is associated with favorable semen-parameter changes and normalization of selected abnormalities in men with impaired semen quality.Reproductive biology and endocrinology : RB&E · 2026Observational
- Sperm DNA Fragmentation in Normozoospermic Men Is Associated with Blastocyst Formation and Quality in Conventional In Vitro Fertilization.Journal of clinical medicine · 2025Article
- Serum 25-Hydroxyvitamin D and Sperm DNA Fragmentation Index In Men Referred For Infertility: A Cross-Sectional Study of 783 Patients.Journal of family & reproductive health · 2025Article
- Sperm DNA Fragmentation Impairs Early Embryo Development but Is Not Predictive of Pregnancy Outcomes: Insights from 870 ICSI Cycles.International journal of molecular sciences · 2025Article
- Understanding the impact of lifestyle and demographic factors on DNA fragmentation index (DFI) among infertile men.BMC urology · 2025Article
- Influence of Bacteriospermia, Host and Lifestyle Factors on Sperm DNA Integrity: A Cross-Sectional Study Based on a Fertility Center of Nepal.Journal of family & reproductive health · 2025Article
- Sperm DNA Fragmentation: Unraveling Its Imperative Impact on Male Infertility Based on Recent Evidence.International journal of molecular sciences · 2024Review
- Review
- Male Clinical Parameters (Age, Stature, Weight, Body Mass Index, Smoking History, Alcohol Consumption) Bear Minimal Relationship to the Level of Sperm DNA Fragmentation.Journal of personalized medicine · 2023Article
- Male Infertility Coexists with Decreased Sperm Genomic Integrity and Oxidative Stress in Semen Irrespective of Leukocytospermia.Antioxidants (Basel, Switzerland) · 2022Article
- Sperm DNA fragmentation in consecutive ejaculates from patients with cancer for sperm cryopreservation.Clinical and experimental reproductive medicine · 2022Article
- Novel mutations of PMFBP1 in a man with acephalic spermatozoa defects.Molecular genetics & genomic medicine · 2022Article
- Article
- Evaluation of selected semen parameters and biomarkers of male infertility - preliminary study.F1000Research · 2022Article
- Abnormal BMI in Male and/or Female Partners Are Deleterious for Embryonic Development and Pregnancy Outcome During ART Process: A Retrospective Study.Frontiers in endocrinology · 2022Article
- A dietary score representing the overall relation of men's diet with semen quality in relation to outcomes of infertility treatment with assisted reproduction.F&S reports · 2021Article
- ISAR Consensus Guidelines on Add-Ons Treatment inJournal of human reproductive sciences · 2021Article
- The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen.International journal of environmental research and public health · 2021Article
- Semen parameters on the intracytoplasmic sperm injection day: Predictive values and cutoff thresholds of success.Clinical and experimental reproductive medicine · 2021Article
- Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMale factor infertility is quite common as 30-50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA fragmentation and could be testicular or post-testicular. The purpose of this study was to assess relationships among sperm DNA fragmentation, lifestyle factors and semen values of Saudi men and to determine impact of sperm DNA fragmentation on ICSI cycle outcome.
methodsThe duration of this study was from January 2015 to June 2016. The cases with female factor infertility were excluded. In total 94 couples were selected for investigation. The study parameters were male age, body mass index, smoking, semen values, % sperm DNA fragmentation, fertilization rate and pregnancy outcome. The ICSI procedure was performed in all patients per standard protocol. The semen samples were grouped based on % sperm DNA fragmentation into < 15%, 15-30 and > 30% which corresponded to low, moderate and high sperm DNA fragmentation, respectively.
resultsThere was no difference in ICSI outcome in low and moderate sperm DNA fragmentation, however, in high sperm DNA fragmentation no patient achieved pregnancy. In this study, 53.19% Saudi men had low, 32.98% moderate and 13.83% high DFI. Semen volume, sperm morphology and fertilization rate did not show any correlation trend with DNA fragmentation, however, sperm concentration and motility were negatively correlated in all DFI categories. The BMI was positively correlated in moderate DFI category and smoking was positively correlated with low DFI category. The age was positively correlated in moderate and high DFI categories.
conclusionsThe results of this study indicated that 14% Saudi men had high DNA fragmentation. The BMI was positively correlated in moderate DFI category and smoking was positively correlated with low DFI category. The age was positively correlated in moderate and high DFI categories.
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