Evidence map›Paper›PMID 29777522›Full record

Observational studyAdvances in therapy2018

Impact of Insulin Degludec in Hospitalized Patients With and Without Type 2 Diabetes Requiring Parenteral/Enteral Nutrition: An Observational Study.

Giuseppe Fatati, Agnese Di Donato, Ilenia Grandone, Pina Menicocci, Eva Mirri, Giuseppe Prosperini, Marco Scardapane, Maria Chiara Rossi, Mariangela Palazzi

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Advances in therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. In-Hospital Management of Hyperglycemia: The Role of Insulin Degludec.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  3. Article
  4. Article
  5. Glycemic Management of Hospitalized Patients Receiving Nutrition Support.Diabetes spectrum : a publication of the American Diabetes Association · 2022
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppe FatatiUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.
Agnese Di DonatoUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.
Ilenia GrandoneUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.
Pina MenicocciUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.
Eva MirriUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.
Giuseppe ProsperiniCORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
Marco ScardapaneCORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
Maria Chiara RossiCORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy. rossi@coresearch.it.ORCID http://orcid.org/0000-0001-8696-4238
Mariangela PalazziUnit of Diabetology, Dietology and Clinical Nutrition, S. Maria Hospital, Terni, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHyperglycemia in inpatients is a major problem, especially when nutritional support is required. This study aims to assess the impact of treatment with insulin degludec (IDeg) on mean blood glucose (BG) and glycemic variability in noncritical hospitalized patients with and without type 2 diabetes (T2DM) receiving enteral and/or parenteral nutrition (EN, PN).

methodsMean BG and glycemic variability from admission up to 7 days of hospitalization were evaluated in consecutive cases with and without T2DM. Percentage of coefficient of variation (CV) for glucose was used to express glycemic variability.

resultsOverall, 26 patients (13 with and 13 without T2DM) were admitted to the hospital for any cause. Subjects were 65.4% men and they were mainly elderly (mean age 66.3 ± 13.4 years). PN was administered in 88.5% of patients and EN in 19.2%. At admission, mean HbA1c level was 5.9 ± 0.7% in patients without diabetes and 9.1 ± 2.5% in patients with T2DM. During hospitalization, mean daily BG levels changed from 151 ± 47.3 mg/dl (day 1) to 157 ± 66.7 mg/dl (day 7) in patients without diabetes and from 210 ± 66.5 mg/dl to 192 ± 48.6 mg/dl in patients with T2DM. CV decreased from 14% (day 1) to 11% (day 7) in patients without diabetes and from 20% (day 1) to 9% (day 7) in patients with T2DM. No symptomatic or severe hypoglycemia occurred.

conclusionsDespite the small sample size and the lack of control group, this study represents the first proof-of-concept that IDeg in hospitalized patients with or without T2DM who require nutritional support has the potential to maintain stable levels of BG and reduce glycemic variability.

fundingNovo Nordisk S.p.A. grant.

Indexed as

Enteral NutritionParenteral NutritionAgedAged, 80 and overBlood GlucoseDiabetes Mellitus, Type 2FemaleHumansHyperglycemiaHypoglycemiaInpatientsInsulin, Long-ActingMaleMiddle AgedBlood GlucoseInsulin, Long-ActingDiabetesEnteral nutritionGlycemic variabilityHospitalized patientsInsulin degludecParenteral nutrition

Identifiers

PMID29777522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.