ArticlePlant molecular biology2018
Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.
Article in Plant molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
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- Xylem Parenchyma Anatomy and Gene Expression Patterns Indicate Mechanisms of Cavitation Resistance inPlant-environment interactions (Hoboken, N.J.) · 2025Article
- A clade of receptor-like cytoplasmic kinases and 14-3-3 proteins coordinate inositol hexaphosphate accumulation.Nature communications · 2024Article
- Genome-wide identification, characterization, and expression analysis of MIPS family genes in legume species.BMC genomics · 2024Article
- ETHYLENE-INSENSITIVE 3-LIKE 2 regulates β-carotene and ascorbic acid accumulation in tomatoes during ripening.Plant physiology · 2023Article
- Transcriptome analysis identifies differentially expressed genes in the progenies of a cross between two low phytic acid soybean mutants.Scientific reports · 2021Article
- GT Factor ZmGT-3b Is Associated With Regulation of Photosynthesis and Defense Response toFrontiers in plant science · 2021Article
- Wheat Myo-inositol phosphate synthase influences plant growth and stress responses via ethylene mediated signaling.Scientific reports · 2020Article
- Article
- A Cotton (International journal of molecular sciences · 2019Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
key messageCo-suppressed MIPS2 transgenic lines allow bypass of the embryo lethal phenotype of the previously published triple knock-out and demonstrate the effects of MIPS on later stages of development. Regulation of inositol production is of interest broadly for its effects on plant growth and development. The enzyme L-myo-inositol 1-phosphate synthase (MIPS, also known as IPS) isomerizes D-glucose-6-P to D-inositol 3-P, and this is the rate-limiting step in inositol production. In Arabidopsis thaliana, the MIPS enzyme is encoded by three different genes, (AtMIPS1, AtMIPS2 and AtMIPS3), each of which has been shown to produce proteins with biochemically similar properties but differential expression patterns. Here, we report phenotypic and biochemical effects of MIPS co-suppression. We show that some plants engineered to overexpress MIPS2 in fact show reduced expression of AtMIPS1, AtMIPS2 and AtMIPS3, and show altered vegetative phenotype, reduced size and root length, and delayed flowering. Additionally, these plants show reduced inositol, increased glucose levels, and alteration of other metabolites. Our results suggest that the three AtMIPS genes work together to impact the overall synthesis of myo-inositol and overall inositol homeostasis.
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