Evidence map›Paper›PMID 29777446›Full record

ArticleVirus genes2018

The degree of HIV-1 amino acid variability is strictly related to different disease progression rates.

Rossana Scutari, Monica Faieta, Roberta D'Arrigo, Lavinia Fabeni, Cristina Mussini, Andrea Cossarizza, Claudio Casoli, Carlo Federico Perno, Valentina Svicher, Claudia Alteri and 1 more

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In one paragraph

Article in Virus genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rossana ScutariDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Monica FaietaGENOMA-Molecular Genetics Laboratory, Rome, Italy.
Roberta D'ArrigoDepartment of Microbiology and Virology, San Camillo-Forlanini Hospital, Rome, Italy.
Lavinia FabeniDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Cristina MussiniDepartment of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy.
Andrea CossarizzaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy.
Claudio CasoliGEMIB Laboratory, Centre for Medical Research and Molecular Diagnostic, Parma, Italy.
Carlo Federico PernoDepartment of Oncology Unit, University of Milan, Milan, Italy.
Valentina SvicherDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Claudia AlteriDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
Stefano AquaroDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. aquaro@uniroma2.it.
University of Rome Tor Vergata · ITUniversity of Modena and Reggio Emilia · ITCarlo Forlanini Hospital · ITUniversity of Calabria · ITUniversity of Milan · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2015W729WH_007
6 · The paper itself

Abstract

The aim of this study is to evaluate the amino acid variability of HIV-1 Gp41, C2-V3, and Nef in a group of patients characterized by different disease progression rates. HIV-1 sequences were collected from 19 Long term non progressor patients (LTNPs), 9 slow progressors (SPs), and 11 rapid progressors (RPs). Phylogenetic trees were estimated by MEGA 6. Differences in amino acid variability among sequences belonging to the 3 groups have been evaluated by amino acid divergence, Shannon entropy analysis, and the number of amino acid mutations (defined as amino acid variations compared with HxB2). The involvement of amino acid mutations on epitope rich regions was also investigated. The population was mainly composed of males (74.3%) and HIV-1 subtype B strains (B: 92.32%, CRF_12BF, A1, C: 2.56% each). Viral load (log

Indexed as

Amino Acid SubstitutionMutationAdultCD4 Lymphocyte CountDisease ProgressionEpitopes, T-LymphocyteFemaleGenotypeHIV-1HIV Envelope Protein gp41HIV InfectionsHumansMaleMiddle AgedPeptidesPhylogenyEpitopes, T-LymphocyteHIV Envelope Protein gp41PeptidesRNA, ViralCTL epitopesDisease progressionHIV-1HIV-1 amino acid Shannon entropyHIV-1 mutation rateHIV-1 variability

Identifiers

PMID29777446
OpenAlexW2803834805

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.