Evidence map›Paper›PMID 29777377›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2018

Radiolabeled F(ab')

P-S Bellaye, M Moreau, O Raguin, A Oudot, C Bernhard, J-M Vrigneaud, L Dumont, D Vandroux, F Denat, A Cochet and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Evaluation of nimotuzumab FabScientific reports · 2023
    Article
  4. Article
  5. Dose predictions for [EJNMMI radiopharmacy and chemistry · 2021
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

P-S BellayeService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France. psbellaye@cgfl.fr.ORCID http://orcid.org/0000-0002-8498-5163
M MoreauInstitut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne Franche-Comté, 21078, Dijon Cedex, France.
O RaguinOncodesign, 21076, Dijon Cedex, France.
A OudotService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France.
C BernhardInstitut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne Franche-Comté, 21078, Dijon Cedex, France.
J-M VrigneaudService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France.
L DumontNVH Medicinal, 64 rue Sully, 21000, Dijon, France.
D VandrouxNVH Medicinal, 64 rue Sully, 21000, Dijon, France.
F DenatInstitut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne Franche-Comté, 21078, Dijon Cedex, France.
A CochetService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France.
F BrunotteService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France.
B CollinService de médecine nucléaire, Centre Georges-François Leclerc, 1 rue du professeur Marion, 21000, Dijon, France.
Centre Georges François Leclerc · FRCentre National de la Recherche Scientifique · FRNVH Medicinal (France) · FR

Funding

Agence Nationale de la Recherche "Investissements d'Avenir" (ANR-10-EQPX-05-01/ IMAPPI Equipex)CNRS 3MIM integrated project ("Marquage de Molécules par les Métaux pour l'Imagerie Médicale")Conseil Régional de Bourgogne the "plan d'actions régional pour l'innovation (PARI)"European Union PO FEDER-FSE Bourgogne 2014/2020 programsUniversité de Bourgogne 3MIM integrated project ("Marquage de Molécules par les Métaux pour l'Imagerie Médicale")
6 · The paper itself

Abstract

purposeThis study aimed to investigate theranostic strategies in colorectal and skin cancer based on fragments of cetuximab, an anti-EGFR mAb, labeled with radionuclide with imaging and therapeutic properties,

methodsWe designed F(ab')

resultsRadiolabeling procedure did not change F(ab')

conclusions

Indexed as

Colorectal NeoplasmsSkin NeoplasmsAnimalsCetuximabHumansImmunoconjugatesImmunoglobulin Fab FragmentsIndium RadioisotopesMiceMice, Inbred BALB CMice, NudeRadioimmunodetectionRadiopharmaceuticalsTheranostic NanomedicineTissue DistributionTomography, Emission-Computed, Single-PhotonCetuximabImmunoconjugatesImmunoglobulin Fab FragmentsIndium-111Indium RadioisotopesRadiopharmaceuticalsCetuximab fragmentsColorectal cancerEGFRHSP90Radioimmunotherapy

Identifiers

PMID29777377
PMCPMC6223717
OpenAlexW2804272866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.