SynthesisSurgical endoscopy2018
Optimizing the image of fluorescence cholangiography using ICG: a systematic review and ex vivo experiments.
Synthesis in Surgical endoscopy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial for the Optimization of Indocyanine Green Administration in Near-infrared Fluorescent Cholangiography During Laparoscopic Cholecystectomy.
An Open Label Cohort Study Assessing the Near Infrared Fluoroscopic Macro and Microscopic Appearances of Paediatric Renal Parenchyma and Tumours Following Ex-vivo Injection of Indocyanine Green
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Indocyanine Green in Bariatric Surgery: a Systematic Review.Obesity surgery · 2023Pooled it
- Comparison of indocyanine green dye fluorescent cholangiography with intra-operative cholangiography in laparoscopic cholecystectomy: a meta-analysis.Surgical endoscopy · 2021Pooled it
- DOse and administration Time of Indocyanine Green in near-infrared fluorescence cholangiography during laparoscopic cholecystectomy (DOTIG): a randomized clinical trial.Surgical endoscopy · 2025Trial
- Intraoperative "white test" for bile leak detection during liver resection: a video vignette.Journal of minimally invasive surgery · 2026Article
- Patient's weight-based indocyanine green dose for fluorescence angiography with led imaging system in left-sided colorectal resections.Surgical endoscopy · 2026Article
- Considerations for transoral robotic surgery with fluorescence imaging: a narrative review.Journal of robotic surgery · 2026Review
- Indocyanine green fluorescence navigation for extrahepatic bile duct visualization in laparoscopic cholecystectomy: a prospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Perspective on Intraoperative Real-Time Biliary Tract Navigation: From Radiological to Fluorescent Imaging.Chemical & biomedical imaging · 2026Review
- Overcoming Anatomical Challenges in Difficult Cholecystectomies: A Narrative Review on the Impact of ICG in Patients with Obesity.Life (Basel, Switzerland) · 2026Review
- Seeing beyond white light: fluorescence for safer laparoscopic cholecystectomy.Frontiers in surgery · 2026Review
- A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy.Biomaterials advances · 2025Article
- Benefits, problems, and optimal timing of administration of indocyanine green fluorescence cholangiography in laparoscopic cholecystectomy.BMJ surgery, interventions, & health technologies · 2025Article
- The application of real-time indocyanine green fluorescence cholangiography in laparoscopic living donor left lateral sectionectomy.Hepatobiliary surgery and nutrition · 2024Article
- Quantitative analysis of intestinal perfusion with indocyanine green (ICG) and methylene blue (MB) using a single clinically approved fluorescence imaging system: a demonstration in a porcine model.Surgical endoscopy · 2024Article
- Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy.World journal of gastrointestinal surgery · 2024Review
- Current applications of indocyanine green (ICG) in abdominal, gynecologic and urologic surgery: a meta-review and quality analysis with use of the AMSTAR 2 instrument.Surgical endoscopy · 2024Review
- Determining the patency of biliary tracts in dogs with gallbladder mucocele using near-infrared cholangiography with indocyanine green.PloS one · 2024Article
- Identification of the ideal weight-based indocyanine green dose for fluorescent cholangiography.Surgical endoscopy · 2023Article
- Indocyanine green dye and its application in gastrointestinal surgery: The future is bright green.World journal of gastrointestinal surgery · 2023Review
- Clinical application of machine learning and computer vision to indocyanine green quantification for dynamic intraoperative tissue characterisation: how to do it.Surgical endoscopy · 2023Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThough often only briefly described in the literature, there are clearly factors that have an influence on the fluorescence intensity, and thereby the usefulness of the technique. This article aims to provide an overview of the factors influencing the fluorescence intensity of fluorescence imaging with Indocyanine green, primarily focussed on NIRF guided cholangiography.
methodsA systematic search was conducted to gain an overview of currently used methods in NIRF imaging in laparoscopic cholecystectomies. Relevant literature was searched to gain advice on what methods to use. Ex vivo experiments were performed to assess various factors that influence fluorescence intensity and whether the found clinical advices can be confirmed.
resultsICG is currently the most widely applied fluorescent dye. Optimal ICG concentration lies between 0.00195 and 0.025 mg/ml, and this dose should be given as early as achievable-but maximum 24 h-before surgery. When holding the laparoscope closer and perpendicular to the dye, the signal is most intense. In patients with a higher BMI and/or cholecystitis, fluorescence intensity is lower, but NIRF seems to be more helpful. There are differences between various marketed fluorescence systems. Also, no uniform method to assess fluorescence intensity is available yet.
conclusionsThis study identified and discussed several factors that influence the signal of fluorescence cholangiography. These factors should be taken into account when using NIRF cholangiography. Also, surgeons should be aware of new dyes and clinical systems, in order to benefit most from the potential of NIRF imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.