Evidence map›Paper›PMID 29777315›Full record

ArticleInternational journal of clinical oncology2018

The MDM2 rs937283 A > G variant significantly increases the risk of lung and gastric cancer in Chinese population.

Bifeng Chen, Jieling Wang, Yucan Chen, Xiuli Gu, Xianhong Feng

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Article in International journal of clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Genetic Variations inCancers · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Bifeng ChenDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China. cbifeng@whut.edu.cn.
Jieling WangDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Yucan ChenDepartment of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Xiuli GuCenter of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xianhong FengClinical Laboratory, Wuhan Xinzhou District People's Hospital, Wuhan, China. xianhong_feng@hotmail.com.

Funding

Fundamental Research Funds for the Central Universities WUT: 2017IVA106National Natural Science Foundation of China 81502427
6 · The paper itself

Abstract

backgroundCurrently, the MDM2 promoter rs937283 A > G variant that is able to alter MDM2 gene expression has been widely studied to explore the association of MDM2 with cancer risk. In this report, we investigate the association of MDM2 rs937283 A > G variant with risk of lung cancer (LC) and gastric cancer (GC) in a Chinese population of Hubei province, which was followed by a meta-analysis.

methodsThe genotyping of rs937283 was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing.

resultsThe results of the present study showed that rs937283 was significantly associated with the risk of LC, and the factors of age, gender, smoking status and drinking status would affect such association. However, rs937283 was only associated with the risk of GC in male, smoking and drinking subgroups. The following meta-analysis demonstrated that rs937283 was associated with the overall cancer risk particularly in Chinese population, which reinforced our present finding. Moreover, the meta-analysis according to cancer types revealed that rs937283 was associated with retinoblastoma risk, but not squamous cell carcinoma risk.

conclusionCollectively, the MDM2 rs937283 A > G variant may be a valuable risk factor or diagnostic biomarker for Chinese cancer patients.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAsian PeopleBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesChinaFemaleGenotypeHumansLung NeoplasmsMaleMiddle AgedProto-Oncogene Proteins c-mdm2RetinoblastomaRisk FactorsBiomarkers, TumorMDM2 protein, humanProto-Oncogene Proteins c-mdm2Gastric cancerLung cancerMDM2Meta-analysisRs937283

Identifiers

PMID29777315

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