Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018
The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 28 citations in OpenAlex.
- A comparison of retinal vascular oxygen saturation between myopic children and adults.BMC ophthalmology · 2026Observational
- The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.Investigative ophthalmology & visual science · 2025Article
- Altered Neuroretinal Tissue in Childhood Cancer Survivors: Data From the German CVSS Study.Translational vision science & technology · 2025Article
- Retinal nerve fiber layer thickness profile in an Iranian adult population.Scientific reports · 2025Article
- Macular ganglion cell complex layer thickness measured with spectral-domain OCT in a large population-based cohort study.BMC ophthalmology · 2025Article
- New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area.Translational vision science & technology · 2025Article
- Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony.Translational vision science & technology · 2024Article
- Prediction of the Cause of Glaucoma Disease Identified by Glaucoma Optical Coherence Tomography Test in Relation to Diabetes and Hypertension at a National Hospital in Seoul: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Association of retinal nerve layers thickness and brain imaging in healthy young subjects from the i-Share-Bordeaux study.Human brain mapping · 2023Article
- Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study.The British journal of ophthalmology · 2023Article
- In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Longitudinal retinal layer changes in preclinical Alzheimer's disease.Acta ophthalmologica · 2021Article
- Determinants of peripapillary retinal nerve fiber layer's grayscale value in normal eyes by spectral domain optical coherence tomography.Scientific reports · 2021Article
- Comparison of the Retinal and Choroidal Structures in 3 Refractive Groups.Beyoglu eye journal · 2021Article
- Thinner retinal nerve fibre layer in healthy myopic eyes with thinner central corneal thickness.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Observational
- Peripapillary Retinal Nerve Fiber Layer Profile in Relation to Refractive Error and Axial Length: Results From the Gutenberg Health Study.Translational vision science & technology · 2020Article
- Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood-Results from a Population-Based Study.Investigative ophthalmology & visual science · 2020Article
- The optic nerve head, lamina cribrosa, and nerve fiber layer in non-myopic and myopic children.Experimental eye research · 2020Article
- Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study.BMC geriatrics · 2020Article
- Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.American journal of ophthalmology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting.
methodsIn the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany). The associated factors in the global and sectoral pRNFL data were analyzed using multivariable linear mixed models related to age, sex, and ocular parameters.
resultsAdvanced age and longer axial length were associated with a thinner pRNFL, whereas pRNFL thickness was independent of sex, intraocular pressure (IOP), and central corneal thickness (CCT). Spherical equivalent was positively associated with pRNFL thickness, except in the temporal pRNFL sector.
conclusionsIn this large, population-based study, pRNFL thickness decreased with age. Longer eyes had thinner pRNFL thickness. Sex, IOP, and CCT showed no significant association with pRNFL thickness. These data may improve the interpretation of pRNFL data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.