ArticleInternational journal of obesity (2005)2018
Does cardiorespiratory fitness moderate the prospective association between physical activity and cardiometabolic risk factors in children?
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Mediation of obesity-related variables in the association between physical fitness and cardiometabolic risk in children and adolescents: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2025Article
- Physical activity and its impact on cardiovascular health in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Fitness and fatness in children and adolescents: investigating their role in the association between physical activity and cardiometabolic health.Biology of sport · 2024Article
- Mediation role of cardiorespiratory fitness on association of physical activity and physical literacy among 8-12 years old children: the PAK-IPPL cross-sectional study.Frontiers in pediatrics · 2024Article
- Associations between Self-Perceived and Desired Health-Related Physical Fitness in Spanish Children.Children (Basel, Switzerland) · 2022Article
- Cross-sectional association between physical fitness and cardiometabolic risk in Chilean schoolchildren: the fat but fit paradox.Translational pediatrics · 2022Article
- Vigorous physical activity is important in maintaining a favourable health trajectory in active children: the CHAMPS Study-DK.Scientific reports · 2021Article
- Neutral Effect of Increased Dairy Product Intake, as Part of a Lifestyle Modification Program, on Cardiometabolic Health in Adolescent Girls With Overweight/Obesity: A Secondary Analysis From a Randomized Controlled Trial.Frontiers in nutrition · 2021Article
- Estimated cardiorespiratory fitness in childhood and cardiometabolic health in adulthood: 1970 British Cohort Study.Scandinavian journal of medicine & science in sports · 2020Article
- Cardiometabolic Risk Factors and Physical Activity Patterns Maximizing Fitness and Minimizing Fatness Variation in Malaysian Adolescents: A Novel Application of Reduced Rank Regression.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPhysical activity (PA) and cardiorespiratory fitness (CRF) are independently associated with reduced cardiometabolic risk in children, and may affect risk through different pathways. This study aims to examine if CRF moderate the prospective association between PA, sedentary time, and cardiometabolic outcomes in 10-year-old children. SUBJECTS/
methodsIn total, 718 children of 1129 (drop out n = 7) had valid measures of PA (accelerometry), CRF (the Andersen running test), and a cardiometabolic risk profile measured at baseline and follow-up 7 months later. Cardiometabolic outcomes were systolic blood pressure, waist circumference (WC), total cholesterol, high-density lipoprotein, triglycerides, glucose, and insulin (HOMA-IR). The cardiometabolic risk factors were analysed individually, and as a clustered risk score (z score). A linear mixed model was used to examine the prospective associations between different PA exposures (overall PA, sedentary time, moderate-to-vigorous PA (MVPA), vigorous PA) and cardiometabolic outcomes, including the interaction term PA × CRF in the model to assess moderation by CRF.
resultsCRF modified the association for baseline overall PA (P < 0.039) and MVPA (min/day) with clustered cardiometabolic risk at follow-up (P < 0.023). Moreover, CRF modified the association between overall PA and MVPA with HOMA-IR independent of WC (P < 0.022). When stratified by CRF level (median split; high/low), MVPA predicted lower HOMA-IR [MVPA β -0.133 (95% CI: -0.223, -0.043); P = 0.004] and clustered cardiometabolic risk [MVPA β -0.094 (95% CI: -0.169, -0.019); P = 0.014] in children with low CRF, but not among their fitter peers (P > 0.232). There was neither direct association between sedentary time and cardiometabolic risk factors in any analyses, nor moderation by CRF.
conclusionCRF significantly moderated the prospective association between PA and the clustered cardiometabolic risk, but not for time spent sedentary. The magnitude of association between MVPA and clustered cardiometabolic risk was stronger in children with low CRF, and no associations appeared present in their high-fit peers.
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