Evidence map›Paper›PMID 29777234›Full record

Trial reportInternational journal of obesity (2005)2019

Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis.

Mads F Hjorth, Trine Blædel, Line Q Bendtsen, Janne K Lorenzen, Jacob B Holm, Pia Kiilerich, Henrik M Roager, Karsten Kristiansen, Lesli H Larsen, Arne Astrup

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 3 syntheses or guidelines pooled it, 262 citations in OpenAlex.

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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mads F HjorthDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark. madsfiil@nexs.ku.dk.ORCID http://orcid.org/0000-0001-9440-2737
Trine BlædelDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Line Q BendtsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Janne K LorenzenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Jacob B HolmLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Pia KiilerichLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Henrik M RoagerDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0002-2504-8313
Karsten KristiansenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6024-0917
Lesli H LarsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Arne AstrupDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.ORCID http://orcid.org/0000-0001-8968-8996
University of Copenhagen · DKBGI Group (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesIndividuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. SUBJECTS/

methodsEighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (≈1500 mg calcium/day) or low ( ≤ 600 mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models.

resultsIndependent of the randomized diets, individuals with high P/B lost 3.8 kg (95%CI, 1.8,5.8; P < 0.001) more body weight and 3.8 kg (95% CI, 1.1, 6.5; P = 0.005) more body fat compared to individuals with low P/B. After adjustment for multiple covariates, individuals with high P/B ratio lost 8.3 kg (95% CI, 5.8;10.9, P < 0.001) more body weight when consuming above compared to below 30 g fiber/10MJ whereas this weight loss was 3.2 kg (95% CI, 0.8;5.5, P = 0.008) among individuals with low P/B ratio [Mean difference: 5.1 kg (95% CI, 1.7;8.6, P = 0.003)]. Partial correlation coefficients between fiber intake and weight change was 0.90 (P < 0.001) among individuals with high P/B ratio and 0.25 (P = 0.29) among individuals with low P/B ratio.

conclusionsIndividuals with high P/B lost more body weight and body fat compared to individuals with low P/B, confirming that individuals with a high P/B are more susceptible to weight loss on a diet rich in fiber.

Indexed as

AdultBacteroidesDietary FiberDiet, ReducingEnergy IntakeFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedNutrientsOverweightPrevotellaRetrospective StudiesRNA, Ribosomal, 16SDietary FiberNutrientsRNA, Ribosomal, 16S

Identifiers

PMID29777234
PMCPMC6331389
OpenAlexW2803629393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.