ArticleScientific reports2018
Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Cervico-vaginal ISGs and interferon tau: emerging biomarkers for early pregnancy detection in cattle.Veterinary research communications · 2026Review
- Epigenetic insights into fertility: involvement of immune cell methylation in dairy cows reproduction†.Biology of reproduction · 2026Article
- Regulation of the maternal immune system during early bovine pregnancy.Reproduction & fertility · 2026Review
- Reduced HSP70 expression under mild hypothermia is involved in bovine embryo growth suppression.The Journal of reproduction and development · 2025Article
- Individual Genomic Loci, Transcript Levels, and Serum Profiles of Immune and Antioxidant Markers Associated with Bacteria-Induced Abortion in Sheep (Veterinary sciences · 2025Article
- Toll-like receptor 2 activation of early divided bovine embryo promotes its viability and development competence in vitro.Scientific reports · 2025Article
- Conceptus signaling markers in immune cells enhance pregnancy prediction in beef cattle.Scientific reports · 2025Article
- Improving Bovine Embryo Development and Quality Using Bovine Oviductal Epithelial Cell-Derived Conditioned Medium (bOEC-CM).Veterinary medicine and science · 2025Article
- Deciphering embryo-maternal cross-talk: advanced in vitro approaches.Animal reproduction · 2025Article
- Effect of IFN-τ on intestinal flora and metabolomics ofFrontiers in microbiology · 2025Article
- Oviduct and endometrial epithelium improve in vitro produced bovine embryo developmental kinetics.Reproduction (Cambridge, England) · 2024Article
- Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development.Journal of animal science and biotechnology · 2024Article
- Morphology of the immune cells in the wall of the human uterine tube and their possible impact on reproduction-uterine tube as a possible immune privileged organ.Frontiers in cell and developmental biology · 2024Review
- Cytokine profile in peripheral blood mononuclear cells differs between embryo donor and potential recipient sows.Frontiers in veterinary science · 2024Article
- Influence of sub-clinical endometritis on early pregnancy predictors and proinflammatory cytokines in circulating immune cells in dairy cows.Animal reproduction · 2024Article
- Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro.Journal of cell communication and signaling · 2023Article
- Association between blood miR-26a levels following artificial insemination, and pregnancy outcome in dairy cattle.PloS one · 2023Article
- From a Passive Conduit to Highly Dynamic Organ. What are the Roles of Uterine Tube Epithelium in Reproduction?Physiological research · 2022Review
- Conceptus-modulated innate immune function during early pregnancy in ruminants: a review.Animal reproduction · 2021Review
- Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue.Journal of molecular medicine (Berlin, Germany) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies indicate that communication between the bovine embryo and the mother begins in the oviduct. Here, we aimed to investigate the effect of embryos on bovine oviducts for their immune responses using an in vitro model. First, zygotes were cultured with or without bovine oviduct epithelial cells (BOECs) for 4 days, when embryos had reached the 16-cell stage. At that time, we detected interferon-tau (IFNT) in embryos co-cultured with BOECs, but not in embryos cultured alone. Next, peripheral blood mononuclear cells (PBMCs) were incubated either in media from embryo alone cultures or from co-cultures of embryos with BOECs. The medium from embryo alone cultures did not modulate PBMCs gene expression; whereas the embryo-BOEC co-culture medium increased interferon-stimulated genes (ISGs: ISG15, OAS1, MX2), STAT1, PTGES and TGFB1 but suppressed IL17 expression in PBMCs. Both IFNT-treated BOEC culture medium and IFNT-supplemented fresh medium alone without BOEC, modulated PBMCs gene expressions similar to those by the embryo-BOEC co-culture medium. Further, specific antibody to IFNT neutralized the effect of embryo-BOEC co-culture medium on PBMCs gene expression. Our results indicate that BOECs stimulate embryos to produce IFNT, which then acts on immune cells to promote an anti-inflammatory response in the oviduct.
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