Evidence map›Paper›PMID 29777191›Full record

ArticleScientific reports2018

Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter.

Kohei Shimizu, Yoko Soroida, Masaya Sato, Hiromi Hikita, Tamaki Kobayashi, Momoe Endo, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Ryosuke Tateishi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Steatotic liver disease and chronic viral hepatitis.Clinical and experimental hepatology · 2025
    Review
  7. Article
  8. Article
  9. Article
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  11. Article
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  13. Article
  14. Article
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  18. [Changes of serum uric acid levels in patients with chronic hepatitis C after using direct antiviral agents therapy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kohei ShimizuDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Yoko SoroidaDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Masaya SatoDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan. masayasato0407@gmail.com.ORCID 0000-0001-5423-9664
Hiromi HikitaDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Tamaki KobayashiDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Momoe EndoDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Mamiko SatoDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Hiroaki GotohDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Tomomi IwaiDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Ryosuke TateishiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yutaka YatomiDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
Hitoshi IkedaDepartment of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPTokyo City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA). We then evaluated the state of hepatic steatosis before and after HCV eradication. We also investigated the changes in serum parameters such as cholesterol and glucose levels. The median value of CAP level decreased significantly after HCV eradication from 273 dB/m to 265 dB/m (P = 0.034). Also, LDL and HDL cholesterol levels increased significantly after HCV eradication (P = 0.002 and P = 0.027, respectively). In conclusion, a decrease in hepatic steatosis after HCV eradication with DAA was revealed in chronic hepatitis C patients with significant steatosis. Cancellation of the viral effect is a possible underlying cause of hepatic steatosis improvement and increase in HDL and LDL cholesterol levels.

Indexed as

AgedAntiviral AgentsBlood GlucoseCholesterol, HDLCholesterol, LDLElasticity Imaging TechniquesFatty LiverFemaleHepacivirusHepatitis C, ChronicHumansLiverMaleMiddle AgedRNA, ViralSeverity of Illness IndexAntiviral AgentsBlood GlucoseCholesterol, HDLCholesterol, LDLRNA, Viral

Identifiers

PMID29777191
PMCPMC5959884
OpenAlexW2804579393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.