ArticleScientific reports2018
Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
What it found
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Who cites it
49 citing papers in PubMed.
- Perspectives on ionizing radiation and Parkinson's disease.NPJ Parkinson's disease · 2026Review
- Potential neuroprotective and therapeutic agents and their mechanisms for irradiation-induced brain injury.Ibrain · 2026Review
- Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta).Radiation research · 2025Review
- Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis.Acta neuropathologica communications · 2025Article
- Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice.Brain, behavior, & immunity - health · 2025Article
- Interplay Between Key Molecular Signaling Pathways and Immune Players Following Brain Irradiation.Mediators of inflammation · 2025Review
- Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cranial irradiation disrupts homeostatic microglial dynamic behavior.Journal of neuroinflammation · 2024Article
- Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health.Frontiers in cellular neuroscience · 2024Review
- New Radiobiological Principles for the CNS Arising from Space Radiation Research.Life (Basel, Switzerland) · 2023Article
- Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats.Life (Basel, Switzerland) · 2023Article
- Review
- Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes.Scientific reports · 2023Article
- Radiation and CNS effects: summary of evidence from a recent symposium of the Radiation Research Society.International journal of radiation biology · 2023Article
- Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.Cell reports · 2022Article
- Microglia as Therapeutic Target for Radiation-Induced Brain Injury.International journal of molecular sciences · 2022Review
- Microglia are involved in the protection of memories formed during sleep deprivation.Neurobiology of sleep and circadian rhythms · 2022Article
- Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.Frontiers in physiology · 2022Article
- Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.Frontiers in immunology · 2022Article
- Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure.Frontiers in physiology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation. The repopulated microglia present a modified functional phenotype with reduced expression of scavenger receptors, lysosome membrane protein and complement receptor, all shown to be involved in microglia-synapses interaction. The lower phagocytic activity observed in the repopulated microglia is paralleled by improved synaptic protein expression. Our data provide mechanistic evidence for the role of microglia in the development of cognitive deficits after cosmic radiation exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.