ArticleScientific reports2018
The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Unexpected variability of gametogenic pathways and interspecific chromosomal leakage in Pelophylax esculentus hybrids†.Biology of reproduction · 2026Article
- From two to one: spatiotemporal mapping of chromatin remodelling in the protamine-lacking early zygote of zebrafish.Epigenetics & chromatin · 2026Article
- Target Capture Sequencing Provides Insights Into Hybridogenetic Water Frogs.Ecology and evolution · 2026Article
- New insights into the molecular basis of gametogenesis in the hybridogenetic water frog Pelophylax esculentus.Scientific reports · 2026Article
- The enigma of the B chromosome-specific behaviour.Frontiers in plant science · 2026Review
- Article
- Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination.Biochemical Society transactions · 2025Review
- Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians.Biology · 2024Review
- Gradual chromosomal lagging drive programmed genome elimination in hemiclonal fishes from the genus Hypseleotris.Scientific reports · 2024Article
- Inheritance patterns of male asexuality in hybrid males of a water frog Pelophylax esculentus.Scientific reports · 2024Article
- A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level.Communications biology · 2024Article
- Karyotypes of water frogs from the Pelophylax esculentus complex: results of cross-species chromosomal painting.Chromosoma · 2023Article
- Delete and survive: strategies of programmed genetic material elimination in eukaryotes.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Genome elimination from the germline cells in diploid and triploid male water frogsFrontiers in cell and developmental biology · 2022Article
- The high diversity of gametogenic pathways in amphispermic water frog hybrids from Eastern Ukraine.PeerJ · 2022Article
- Maintenance of pure hybridogenetic water frog populations: Genotypic variability in progeny of diploid and triploid parents.PloS one · 2022Article
- Uniparental Genome Elimination in Australian Carp Gudgeons.Genome biology and evolution · 2021Article
- New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction.Genome biology and evolution · 2021Article
- Causes and consequences of micronuclei.Current opinion in cell biology · 2021Review
- Article
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10 authors.
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Abstract
DNA elimination is a radical form of gene silencing and occurs both in somatic and germ cells. The programmed DNA elimination occurs during gametogenesis in interspecies hybrids that reproduce by hybridogenesis (stick insects, fishes, and amphibians) and concerns removal of whole genomes of one of the parental species and production of clonal gametes propagating the genome of the other species. The cellular mechanisms differ considerably in hybridogenetic insects and fishes but remains unknown in edible frogs Pelophylax esculentus, natural hybrids between Pelophylax lessonae and Pelophylax ridibundus. Here we report DNA elimination mechanism in early developing gonads of diploid and triploid hybrid frogs, studied by TEM, immunofluorescence, and cytochemistry. In gonocytes of both sexes (primary oogonia and prespermatogonia), micronuclei emerge as detached nuclear buds formed during interphase. We found depletion of nuclear pore complexes in micronuclear membrane and chromatin inactivation via heterochromatinization followed by degradation of micronuclei by autophagy. Micronuclei formation does not lead to apoptotic cell death showing that genome elimination is a physiological process. Chromatin elimination via micronuclei in P. esculentus is unique among hybridogenetic animals and contributes to broadening the knowledge about reproductive modes in animals.
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