Evidence map›Paper›PMID 29777110›Full record

ArticleScientific reports2018

Using network analysis for the prediction of treatment dropout in patients with mood and anxiety disorders: A methodological proof-of-concept study.

Wolfgang Lutz, Brian Schwartz, Stefan G Hofmann, Aaron J Fisher, Kristin Husen, Julian A Rubel

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. Individual-Specific Animated Profiles of Mental Health.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
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  13. The Dialectical Relationship Between Burnout and Work Engagement: A Network Approach.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
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  16. Predicting the outcome of psychotherapy for chronic depression by person-specific symptom networks.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wolfgang LutzDepartment of Psychology, University of Trier, Trier, Germany. wolfgang.lutz@uni-trier.de.ORCID 0000-0002-4372-7248
Brian SchwartzDepartment of Psychology, University of Trier, Trier, Germany.ORCID 0000-0003-4695-4953
Stefan G HofmannDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, United States.ORCID 0000-0002-3548-9681
Aaron J FisherDepartment of Psychology, University of California, Berkeley, CA, United States.
Kristin HusenDepartment of Psychology, University of Trier, Trier, Germany.
Julian A RubelDepartment of Psychology, University of Trier, Trier, Germany.ORCID 0000-0002-9625-6611

Funding

Connectomes Related to Anxiety and Depression in AdolescentsU01MH108168 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN, WHITFIELD-GABRIELI, SUSAN · 2015 to 2019
$4.6M
Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum DisordersR01MH099021 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2012 to 2015
$2.7M
1/2-Yoga For Generalized Anxiety DisorderR01AT007257 · NCCIH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HOFMANN, STEFAN G. · 2013 to 2017
$2.0M
NCCIH NIH HHS R01 AT007257NIMH NIH HHS R01 MH099021NIMH NIH HHS U01 MH108168
6 · The paper itself

Abstract

There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological treatment for mood or anxiety disorders were assessed using Ecological Momentary Assessments four times a day for two weeks before treatment (3,248 measurements). Multilevel vector autoregressive models were employed to compute dynamic symptom networks. Intake variables and network parameters (centrality measures) were used as predictors for dropout using machine-learning algorithms. Networks for patients differed significantly between completers and dropouts. Among intake variables, initial impairment and sex predicted dropout explaining 6% of the variance. The network analysis identified four additional predictors: Expected force of being excited, outstrength of experiencing social support, betweenness of feeling nervous, and instrength of being active. The final model with the two intake and four network variables explained 32% of variance in dropout and identified 47 out of 58 patients correctly. The findings indicate that patients' dynamic network structures may improve the prediction of dropout. When implemented in routine care, such prediction models could identify patients at risk for attrition and inform personalized treatment recommendations.

Indexed as

AdultAnxiety DisordersBehavior TherapyFemaleHumansMachine LearningMaleMiddle AgedModels, PsychologicalMood DisordersPatient DropoutsPrecision MedicineProof of Concept StudySex FactorsYoung Adult

Identifiers

PMID29777110
PMCPMC5959887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.