Evidence map›Paper›PMID 29777057›Full record

ArticleThe Journal of biological chemistry2018

Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.

Kelsie J Faulds, Jennifer N Egelston, Laura J Sedivy, Matthew K Mitchell, Sanjana Garimella, Hanna Kozlowski, Angelo D'Alessandro, Kirk C Hansen, Jeremy L Balsbaugh, Christopher J Phiel

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  7. Article
  8. Article
  9. Review
  10. Review
  11. The regulatory role of mGenes & diseases · 2024
    Review
  12. LncRNA CCRR maintains CaScience China. Life sciences · 2024
    Article
  13. Article
  14. Ubiquitination and deubiquitination in the regulation of NJournal of molecular medicine (Berlin, Germany) · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. GSK3Oxidative medicine and cellular longevity · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kelsie J FauldsFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Jennifer N EgelstonFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Laura J SedivyFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Matthew K MitchellFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Sanjana GarimellaFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Hanna KozlowskiFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204.
Angelo D'Alessandrothe Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado 80045, and.
Kirk C Hansenthe Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado 80045, and.
Jeremy L Balsbaughthe Mass Spectrometry Core Facility, Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309.ORCID 0000-0002-1852-8749
Christopher J PhielFrom the Department of Integrative Biology, University of Colorado Denver, Denver, Colorado 80204, christopher.phiel@ucdenver.edu.ORCID 0000-0002-9265-2676
University of Denver · USUniversity of Colorado Denver · USUniversity of Colorado Boulder · US

Funding

The Regulation of mRNA Methylation by Glycogen Synthase Kinase-3R15GM119103 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PHIEL, CHRISTOPHER J · 2016 to 2019
$933k
NIGMS NIH HHS R15 GM119103
6 · The paper itself

Abstract

Glycogen synthase kinase-3 (GSK-3) activity regulates multiple signal transduction pathways and is also a key component of the network responsible for maintaining stem cell pluripotency. Genetic deletion of

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsCells, CulturedGlycogen Synthase Kinase 3MethylationMiceMice, KnockoutMouse Embryonic Stem CellsPhosphorylationRNA, MessengerUbiquitinationAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseGlycogen Synthase Kinase 3N-methyladenosineRNA, Messengerpluripotencyprotein phosphorylationRNA methylationstem cellsubiquitin

Identifiers

PMID29777057
PMCPMC6036209
OpenAlexW2803317247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.