Evidence map›Paper›PMID 29777034›Full record

ArticleJournal of cell science2018

Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPα.

Jan Steinkühler, Bartosz Różycki, Cory Alvey, Reinhard Lipowsky, Thomas R Weikl, Rumiana Dimova, Dennis E Discher

Abstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  6. Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Two-dimensional measurements of receptor-ligand interactions.Frontiers in molecular biosciences · 2023
    Review
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  19. Membrane-Mediated Interactions Between Protein Inclusions.Frontiers in molecular biosciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Jan SteinkühlerMolecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, 19104 PA, USA.
Bartosz RóżyckiInstitute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw, Poland.
Cory AlveyMolecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, 19104 PA, USA.
Reinhard LipowskyTheory and Bio-Systems, Max Planck Institut of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany.
Thomas R WeiklTheory and Bio-Systems, Max Planck Institut of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany.
Rumiana DimovaTheory and Bio-Systems, Max Planck Institut of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany.
Dennis E DischerMolecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, 19104 PA, USA discher@seas.upenn.edu.ORCID 0000-0001-6163-2229
Max Planck Institute of Colloids and Interfaces · DEUniversity of Pennsylvania · USPolish Academy of Sciences · PL

Funding

PSOC@Penn Education and OutreachU54CA193417 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2015 to 2020
$10.5M
Nanoscience of 'Self' - reductionist approaches to hCD47 inhibition of phagocytesR01HL124106 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2014 to 2022
$3.1M
Nuclear Mechanics varies with Tissue Mechanics & Regulates CytoskeletonR21HL128187 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DISCHER, DENNIS E. · 2015 to 2016
$426k
NCI NIH HHS U54 CA193417NHLBI NIH HHS R01 HL124106NHLBI NIH HHS R21 HL128187
6 · The paper itself

Abstract

Cell-cell interactions that result from membrane proteins binding weakly in

Indexed as

AcidosisAntigens, DifferentiationBiomarkersCD47 AntigenHumansMacrophagesNeoplasmsPhagocytosisProtein BindingReceptors, ImmunologicSignal TransductionAntigens, DifferentiationBiomarkersCD47 AntigenCD47 protein, humanReceptors, ImmunologicSIRPA protein, humanAdhesionCooperative bindingElasticityGPMVVesicles

Identifiers

PMID29777034
PMCPMC6398477
OpenAlexW2803345086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.