ArticleDrug metabolism and disposition: the biological fate of chemicals2018
Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity.
Stanislav G Yanev, Tsveta D Stoyanova, Violeta V Valcheva, Paul R Ortiz de Montellano
Open access · bronzeAbstract read
In one paragraphArticle in Drug metabolism and disposition: the biological fate of chemicals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
4 authors at 3 institutions in 2 countries.
Stanislav G YanevDepartment of Drug Toxicology, Institute of Neurobiology (S.G.Y., T.D.S.), and Institute of Microbiology (V.V.V.), Bulgarian Academy of Sciences, Sofia, Bulgaria; and Department of Pharmaceutical Chemistry, University of California, San Francisco, California (P.R.O.M.) stanislav_yanev@yahoo.com.
Tsveta D StoyanovaDepartment of Drug Toxicology, Institute of Neurobiology (S.G.Y., T.D.S.), and Institute of Microbiology (V.V.V.), Bulgarian Academy of Sciences, Sofia, Bulgaria; and Department of Pharmaceutical Chemistry, University of California, San Francisco, California (P.R.O.M.).
Violeta V ValchevaDepartment of Drug Toxicology, Institute of Neurobiology (S.G.Y., T.D.S.), and Institute of Microbiology (V.V.V.), Bulgarian Academy of Sciences, Sofia, Bulgaria; and Department of Pharmaceutical Chemistry, University of California, San Francisco, California (P.R.O.M.).
Paul R Ortiz de MontellanoDepartment of Drug Toxicology, Institute of Neurobiology (S.G.Y., T.D.S.), and Institute of Microbiology (V.V.V.), Bulgarian Academy of Sciences, Sofia, Bulgaria; and Department of Pharmaceutical Chemistry, University of California, San Francisco, California (P.R.O.M.).
Bulgarian Academy of Sciences · BGInstitute of Neurobiology · BGUniversity of California, San Francisco · US
Funding
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosisR01AI074824 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ORTIZ DE MONTELLANO, PAUL R · 2007 to 2016
$4.3MNIAID NIH HHS R01 AI074824
6 · The paper itselfAbstract
Ethionamide (ETH) plays a central role in the treatment of tuberculosis in patients resistant to the first-line drugs. The ETH, thioamide, and thiourea class of antituberculosis agents are prodrugs that are oxidatively converted to their active
Indexed as
Anti-Bacterial AgentsAntitubercular AgentsBacterial ProteinsEthionamideFlavoproteinsHumansMicrobial Sensitivity TestsMixed Function OxygenasesMycobacterium tuberculosisOxidation-ReductionOxygenasesProdrugsAnti-Bacterial AgentsAntitubercular AgentsBacterial ProteinsEthionamideFlavoproteinsMixed Function OxygenasesOxygenasesProdrugs
Identifiers
PMID29777023
PMCPMC6034259
OpenAlexW2803688491
What OpenQuestion holds
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