Evidence map›Paper›PMID 29777010›Full record

ArticleDevelopment (Cambridge, England)2018

Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.

Gowri Nayak, Yoshinobu Odaka, Vikram Prasad, Alyssa F Solano, Eun-Jin Yeo, Shruti Vemaraju, Jeffery D Molkentin, Andreas Trumpp, Bart Williams, Sujata Rao and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  10. Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome.Frontiers in cell and developmental biology · 2022
    Review
  11. Article
  12. Article
  13. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. The transcription factorDisease models & mechanisms · 2020
    Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Gowri NayakThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-5106-5192
Yoshinobu OdakaThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-3966-5475
Vikram PrasadDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Alyssa F SolanoThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Eun-Jin YeoThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Shruti VemarajuThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Jeffery D MolkentinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Andreas TrumppHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Bart WilliamsCenter for Skeletal Disease Research and Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Sujata RaoDivisions of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA raos7@ccf.org Richard.Lang@cchmc.org.ORCID 0000-0003-2315-1234
Richard A LangThe Visual Systems Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA raos7@ccf.org Richard.Lang@cchmc.org.ORCID 0000-0002-5212-254X
Cincinnati Children's Hospital Medical Center · USGerman Cancer Research Center · DEVan Andel Institute · US

Funding

Regulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4M
Regulation of eye development by an Opsin5-dopamine pathwayR01EY027711 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL, LANG, RICHARD A. · 2017 to 2020
$1.9M
Retinal Microglia and AngiogenesisR01EY021636 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A. · 2012 to 2016
$1.9M
NEI NIH HHS R01 EY021636NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY027711
6 · The paper itself

Abstract

Normal development requires tight regulation of cell proliferation and cell death. Here, we have investigated these control mechanisms in the hyaloid vessels, a temporary vascular network in the mammalian eye that requires a Wnt/β-catenin response for scheduled regression. We investigated whether the hyaloid Wnt response was linked to the oncogene

Indexed as

AnimalsApoptosisbeta CateninCell LineCell ProliferationCyclin-Dependent Kinase Inhibitor p21Endothelial CellsEndothelium, VascularEyeHEK293 CellsHumansLow Density Lipoprotein Receptor-Related Protein-5Low Density Lipoprotein Receptor-Related Protein-6MiceMice, KnockoutProto-Oncogene Proteins c-mycbeta CateninCdkn1a protein, mouseCTNNB1 protein, mouseCyclin-Dependent Kinase Inhibitor p21Low Density Lipoprotein Receptor-Related Protein-5Low Density Lipoprotein Receptor-Related Protein-6Lrp5 protein, mouseLrp6 protein, mouseMyc protein, mouseProto-Oncogene Proteins c-mycCDKN1AEndothelial cellHyaloidMYCP21Vascular regressionWnt signaling

Identifiers

PMID29777010
PMCPMC6031408
OpenAlexW2803394663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.