Evidence map›Paper›PMID 29776960›Full record

Trial reportJournal of the American Heart Association2018

Effect of Combined Treatment With Folic Acid, Vitamin B

William G Christen, Nancy R Cook, Martin Van Denburgh, Elaine Zaharris, Christine M Albert, JoAnn E Manson

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000541 (Women's Antioxidant and Folic Acid Cardiovascular Study), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000541 phase2completednot on this map

Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)

TypeinterventionalSponsorBrigham and Women's HospitalRan1993 to 2005ConditionsCardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart DiseasesArmsdietary supplements, vitamin C, vitamin E, beta-carotene, folic acid/Vitamin B6/Vitamin B12
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Emerging Roles of Vitamin BInternational journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Observational
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Nutrition and Cardiovascular Health.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

William G ChristenDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA wchristen@rics.bwh.harvard.edu.
Nancy R CookDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA.
Martin Van DenburghDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA.
Elaine ZaharrisDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA.
Christine M AlbertDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USHarvard University · US

Funding

TRIAL OF ANTIOXIDANT THERAPY OF CVD IN WOMENR01HL046959 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MANSON, JOANN ELISABETH · 1993 to 2005
$3.6M
Folic Acid, B-Vitamins and AMD: Blood and Diet-based StudiesR01EY018820 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTEN, WILLIAM G · 2009 to 2012
$921k
NEI NIH HHS R01 EY018820NHLBI NIH HHS R01 HL046959
6 · The paper itself

Abstract

backgroundThe aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B METHODS AND

resultsWe conducted a blood substudy of 300 treatment-adherent participants (150 in the active treatment group, 150 in the placebo group) in the WAFACS (Women's Antioxidant and Folic Acid Cardiovascular Study), a randomized, double-blind, placebo-controlled trial testing a daily combination of folic acid (2.5 mg), vitamin B

conclusionsThese findings indicate that long-term, combined treatment with folic acid, vitamin B CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00000541.

Indexed as

AgedBiomarkersCardiovascular DiseasesDouble-Blind MethodDrug CombinationsEndothelium, VascularFemaleFolic AcidHomocysteineHumansInflammationInflammation MediatorsMiddle AgedTime FactorsTreatment OutcomeVitamin B 12BiomarkersDrug CombinationsFolic AcidHomocysteineInflammation MediatorsVitamin B 12Vitamin B 6VitaminsbiomarkersB vitaminscardiovascular diseaseendothelial dysfunctioninflammationrandomized trial

Identifiers

PMID29776960
PMCPMC6015379
OpenAlexW2803846134

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.