ArticleBMC research notes2018
Anti-plasmodial activities of Combretum molle (Combretaceae) [Zwoo] seed extract in Swiss albino mice.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of AfricanAntibiotics (Basel, Switzerland) · 2023Review
- Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies.Malaria journal · 2022Review
- Potential anti-Heliyon · 2021Article
- Antimalarial Activity of Methanolic Extracts and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Evaluation of Antimalarial Activity of the 80% Methanolic Stem Bark Extract ofJournal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObjective of the study was to evaluate in vivo anti-plasmodial activities of Combretum molle seed extract.
methodsAs a standard protocol, initially the acute toxicity of the plant seed extract was checked following single administration of crude seed extract of the plant at doses 500, 1000 and 2000 mg/kg. This was followed by evaluation of anti-plasmodial activity of crude seed extract of the plant following a 4 days suppressive test.
resultsIn acute toxicity study sign of toxicity was not observed. Also physical and behavioural changes were not detected. The crude seed extract of C. molle showed, 63.5% parasite suppression in mice infected with Plasmodium berghei ANKA (PbA) murine parasite and treated with 250 mg/kg of seed extract of C. molle. Relative survival time of mice treated with 250 mg/kg showed significantly longer survival than the negative control, while lower than mice treated with the standard drug, chloroquine. The plant seed extract on day-4 post-infection showed significant (P < 0.05) protection against body weight reduction, high body temperature and hemolysis of RBC at relatively lower doses. At optimum dose the crude extract of C. molle seed has good chemo-suppressive activity against PbA parasite and improved some clinical symptoms of malaria in mice.
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