ArticleRadiation oncology (London, England)2018
The impact of contour variation on tumour control probability in anal cancer.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Intelligent Support for Radiotherapy: A Review of Clinical Applications for Large Language Models.Journal of clinical medicine · 2026Review
- Geometric and dosimetric evaluation of a commercial AI auto-contouring tool on multiple anatomical sites in CT scans.Journal of applied clinical medical physics · 2025Article
- A deep learning-based self-adapting ensemble method for segmentation in gynecological brachytherapy.Radiation oncology (London, England) · 2022Article
- Impact of Peer Review in the Radiation Treatment Planning Process: Experience of a Tertiary Care University Hospital in Pakistan.Journal of global oncology · 2019Article
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Authors and funding
6 authors.
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Abstract
backgroundWhile intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour variation on tumour control probability (TCP) when using IMRT for AC.
methodsNine Australian centres contoured a single computed tomography dataset of a patient with AC. The same optimised template-based IMRT planning protocol was applied to each contour set to generate nine representative treatment plans and their corresponding dose volume histograms. A geometric analysis was performed on all contours. The TCP was calculated for each plan using the linear quadratic and logitEUD model.
resultsThe median concordance index (CI) for the bladder, head and neck of femur, bone marrow, small bowel and external genitalia was 0.94, 0.88, 0.84, 0.65 and 0.65, respectively. The median CI for the involved nodal, primary tumour and elective clinical target volumes were 0.85, 0.77 and 0.71, respectively. Across the nine plans, the TCP was not significantly different. Variation in TCP between plans increased as tumour cell load increased or radiation dose decreased.
conclusionsWhen using IMRT for AC, contour variations generated from a common protocol within the limits of minor deviations do not appear to have a significant impact on TCP. Contouring variations may be more critical with increasing tumour cell load or reducing radiotherapy dose.
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