ArticleBMC complementary and alternative medicine2018
GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07240246 (Effect of a Dietary Supplement), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Dietary Supplement (FitLine TopShape) on the Incretin Response
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
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- Boosting GLP-1 by Natural Products.Advances in experimental medicine and biology · 2021Article
- The Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions.International journal of medical sciences · 2021Article
- Methanol leaf extract ofVeterinary world · 2020Article
- Correction to: GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia.BMC complementary and alternative medicine · 2018Article
- Correction to: GLP-I Secretion in Healthy and Diabetic Wistar Rats in Response to Aqueous Extract of Momordica charantia.BMC complementary and alternative medicine · 2018Article
- The systemic anti-diabetic effect of polyherbal formulation Varanadi Kashayam is mediated through GLP-1 secretion and DPP4 inhibition.Journal of Ayurveda and integrative medicineArticle
- Antidiabetic Activity ofAvicenna journal of medical biotechnologyArticle
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDiabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of Momordica charantia (AEMC) on fasting blood glucose (FBG), tissue glycogen, glycosylated haemoglobin, plasma concentrations of insulin and GLP-1 hormone (glucagon-like peptide 1) in healthy and diabetic wistar rats.
methodsMale Wistar rats (both normal and diabetic) were treated with AEMC by gavaging (300 mg/kg body wt/day for 28 days).
resultsAEMC was found to increase tissue glycogen, serum insulin and GLP-1 non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats, whereas decrease in FBG and Glycosylated haemoglobin non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats. The elevation of GLP-1 level in normal and diabetic treated groups may be due to the L-cell regeneration and proliferation by binding with L-cell receptors and makes a conformational change, resulting in the activation of a series of signal transducers. The polar molecules of M. charantia also depolarize the L-cell through elevation of intracellular Ca
conclusionThe findings tend to provide a possible explanation for the hypoglycemic action of M. charantia fruit extracts as alternative nutritional therapy in the management and treatment of diabetes.
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Registered trials
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