Evidence map›Paper›PMID 29776407›Full record

ArticleBMC biology2018

Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum.

Amelia R I Lindsey, Yogeshwar D Kelkar, Xin Wu, Dan Sun, Ellen O Martinson, Zhichao Yan, Paul F Rugman-Jones, Daniel S T Hughes, Shwetha C Murali, Jiaxin Qu and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  6. Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  9. Parthenogenesis in dipterans: a genetic perspective.Proceedings. Biological sciences · 2023
    Review
  10. Article
  11. Posterior concentration ofFrontiers in cellular and infection microbiology · 2023
    Article
  12. Article
  13. Article
  14. Whole-genome sequencing analysis and protocol for RNA interference of the endoparasitoid wasp Asobara japonica.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Amelia R I LindseyDepartment of Entomology, University of California Riverside, Riverside, California, 92521, USA. alind005@ucr.edu.
Yogeshwar D KelkarDepartment of Biology, University of Rochester, Rochester, New York, 14627, USA.
Xin WuSchool of Biological Sciences, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
Dan SunSchool of Biological Sciences, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
Ellen O MartinsonDepartment of Biology, University of Rochester, Rochester, New York, 14627, USA.
Zhichao YanDepartment of Biology, University of Rochester, Rochester, New York, 14627, USA.
Paul F Rugman-JonesDepartment of Entomology, University of California Riverside, Riverside, California, 92521, USA.
Daniel S T HughesHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Shwetha C MuraliHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Jiaxin QuHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Shannon DuganHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Sandra L LeeHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Hsu ChaoHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Huyen DinhHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Yi HanHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Harsha Vardhan DoddapaneniHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Kim C WorleyHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Donna M MuznyHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Gongyin YeState Key Laboratory of Rice Biology & Ministry of Agriculture Key Laboratory of Agricultural Entomology, Institute of Insect Sciences, Zhejiang University, Hangzhou, 310058, China.
Richard A GibbsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Stephen RichardsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
Soojin V YiSchool of Biological Sciences, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA.
Richard StouthamerDepartment of Entomology, University of California Riverside, Riverside, California, 92521, USA. richards@ucr.edu.
John H WerrenDepartment of Biology, University of Rochester, Rochester, New York, 14627, USA. jack.werren@rochester.edu.
Baylor Genetics · USBaylor College of Medicine · USGeorgia Institute of Technology · USUniversity of California, Riverside · USUniversity of Rochester · USState Key Laboratory of Rice Biology

Funding

The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
NHGRI NIH HHS U54 HG003273
6 · The paper itself

Abstract

backgroundTrichogrammatids are minute parasitoid wasps that develop within other insect eggs. They are less than half a millimeter long, smaller than some protozoans. The Trichogrammatidae are one of the earliest branching families of Chalcidoidea: a diverse superfamily of approximately half a million species of parasitoid wasps, proposed to have evolved from a miniaturized ancestor. Trichogramma are frequently used in agriculture, released as biological control agents against major moth and butterfly pests. Additionally, Trichogramma are well known for their symbiotic bacteria that induce asexual reproduction in infected females. Knowledge of the genome sequence of Trichogramma is a major step towards further understanding its biology and potential applications in pest control.

resultsWe report the 195-Mb genome sequence of Trichogramma pretiosum and uncover signatures of miniaturization and adaptation in Trichogramma and related parasitoids. Comparative analyses reveal relatively rapid evolution of proteins involved in ribosome biogenesis and function, transcriptional regulation, and ploidy regulation. Chalcids also show loss or especially rapid evolution of 285 gene clusters conserved in other Hymenoptera, including many that are involved in signal transduction and embryonic development. Comparisons between sexual and asexual lineages of Trichogramma pretiosum reveal that there is no strong evidence for genome degradation (e.g., gene loss) in the asexual lineage, although it does contain a lower repeat content than the sexual lineage. Trichogramma shows particularly rapid genome evolution compared to other hymenopterans. We speculate these changes reflect adaptations to miniaturization, and to life as a specialized egg parasitoid.

conclusionsThe genomes of Trichogramma and related parasitoids are a valuable resource for future studies of these diverse and economically important insects, including explorations of parasitoid biology, symbiosis, asexuality, biological control, and the evolution of miniaturization. Understanding the molecular determinants of parasitism can also inform mass rearing of Trichogramma and other parasitoids for biological control.

Indexed as

Evolution, MolecularPest Control, BiologicalAnimalsGenomicsMothsPhylogenyWaspsWhole Genome SequencingBiological controlChalcidoideaComparative genomicsMethylationMiniaturizationParthenogenesisSymbiosisWolbachia

Identifiers

PMID29776407
PMCPMC5960102
OpenAlexW2803113341

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.