Evidence map›Paper›PMID 29776362›Full record

ArticleLipids in health and disease2018

Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients.

Xiaojiang Zhan, Yanbing Chen, Caixia Yan, Siyi Liu, Lijuan Deng, Yuting Yang, Panlin Qiu, Dan Pan, Bingxiang Zeng, Qinkai Chen

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. The Impact of Acute Nutritional Interventions on the Plasma Proteome.The Journal of clinical endocrinology and metabolism · 2023
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  17. The effect of chronic kidney disease on lipid metabolism.International urology and nephrology · 2019
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaojiang ZhanDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Yanbing ChenDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Caixia YanDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Siyi LiuDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Lijuan DengDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Yuting YangDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Panlin QiuDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Dan PanDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Bingxiang ZengDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China.
Qinkai ChenDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, 17# yongwai street, Nanchang, 330006, Jiangxi, China. timmyclz@163.com.
First Affiliated Hospital of Nanchang University · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients.

methodsEight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models.

resultsOf the 860 patients, the mean age was 49.9 ± 14.5 years, 57.6% were men, and 19.3% were diabetic patients. The median apo B/apo A1 ratio was 0.65 (range: 0.22-2.24). During a median follow-up period of 27 months (interquartile range, 13 - 41 months), 202 deaths, and 145 cardiovascular events were recorded. After adjustment for age, sex, body mass index, diabetes, cardiovascular disease, systolic blood pressure, total Kt/V, estimated glomerular filtration rate, hemoglobin level, neutrophil to lymphocyte ratio and albumin, triglyceride, and cholesterol, as well as the use of lipid-lowering agents, the highest apo B/apo A1 ratio tertile was significantly associated with a hazard ratio for all-cause mortality of 1.60 (95% CI: 1.02 to 2.49, P = 0.040) and for cardiovascular events of 2.04 (95% CI: 1.21 to 3.44, P = 0.008).

conclusionAn increased apo B/apo A1 ratio was independently associated with all-cause mortality and cardiovascular events in PD patients.

Indexed as

AdultAgedAge FactorsApolipoprotein A-IApolipoprotein B-100Blood PressureCardiovascular DiseasesCholesterolDiabetes MellitusFemaleGene ExpressionGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedAPOA1 protein, humanAPOB protein, humanApolipoprotein A-IApolipoprotein B-100CholesterolSerum AlbuminTriglyceridesApolipoproteinCardiovascular eventCohort studyMortalityPeritoneal dialysis

Identifiers

PMID29776362
PMCPMC5960196
OpenAlexW2807590850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.