ArticlePhytochemistry2018
Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica.
Article in Phytochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Untargeted Chemical Profile, Antioxidant, and Enzyme Inhibition Activity ofAntioxidants (Basel, Switzerland) · 2025Article
- Effects of Seed Processing with Cold Plasma on Growth and Biochemical Traits ofPlants (Basel, Switzerland) · 2025Article
- An Integrated Strategy of UHPLC-ESI-MS/MS Combined with Bioactivity-Based Molecular Networking for Identification of Antitumoral Withanolides fromMolecules (Basel, Switzerland) · 2024Article
- Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica.Journal of natural medicines · 2023Article
- Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs.Molecules (Basel, Switzerland) · 2023Review
- Antitumor Potential of Withanolide Glycosides from Ashwagandha (Antioxidants (Basel, Switzerland) · 2022Article
- Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review.Nutrients · 2022Review
- Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Journal of ginseng research · 2022Article
- Structural Characterization of Withanolide Glycosides from the Roots ofPlants (Basel, Switzerland) · 2022Article
- Hidden in Plants-A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies.Cancers · 2022Review
- Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically GrownMolecules (Basel, Switzerland) · 2022Article
- Effect of different dietary inclusion levels of whole plant green tomato (Frontiers in veterinary science · 2022Article
- Correction.Plant signaling & behavior · 2021Article
- Metabolic response to larval herbivory in threePlant signaling & behavior · 2021Article
- Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Pharmaceuticals (Basel, Switzerland) · 2021Article
- A review of nutritional properties and health benefits of Physalis species.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Eleven withanolides including six previously undescribed compounds, 16β-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.